Effect Of Compound Diandao Pulvis Drug Facial Mask On Acne Model Of Rabbit’s Ears And The Clinical Study In Acne Vulgaris

Acne is a common clinical sebaceous follicles chronic inflammatory disease, especially in the highest incidence of adolescence,the loss is a common capacitive disease,manifested as acne,papules,pustules,nodules,cysts and scar,good in the face,back,chest and other parts of the rich sebaceous,or even individual patients with depression or hypertrophic scar,which has seriously affected the quality of life of patients.And the occurrence of acne androgen high cortex gland secretion increased catheter abnormal sebaceous follicles keratosis,and the proliferation of Propionibacterium acnes and other relevant genetic factors.Acne current use of western medicine treatment(such as anti-male hormones and anti-inflammatory) oral or peacekeeping A cream acid,benzoyl peroxide, antibiotics and topical preparations for treatment,because of its side effects,it can not be long-term applications,and there pigmentation,easy to relapse after treatment,and other shortcomings,many patients are not easy to accept.Chinese medicine is effective in the treatment of acne,and smaller security toxicity.Reversed Powder("doctors in the Kam") from SulpHur,rhubarb composition of the two drugs,TCM is a classic topical treatment of acne,in the widespread clinical application,the use of powder or paste,tincture or liniment,has done mould mask to treat acne.Professor Yang increase aloe based on the patient condition,Mr Wong,such as Chinese medicine Kushen,in the clinical treatment achieved good results.On this basis,we created a formula CDP the treatment of acne, as a routine treatment of acne medication,and achieved good results.Compound Diandao Pulvis make from SulpHur,rhubarb,PHellodendron,Kushen, the composition of aloe.Modern pHarmacological research has shown that:the sulfur and sulfur-generated skin secretions role sulfide can soften skin,a degreasing, disinfection,and antipruritic horny contributed role of rhubarb on Propionibacterium acnes bacteria,such as StapHylococcus aureus has strong The inhibition of StapHylococcus aureus Huangbai,Propionibacterium acnes bacteria,StapHylococcus aureus,such as white obvious inhibitory role in the play and PHellodendron antibacterial role of the fair antidote to promote angiogenesis,the rapid elimination of inflammatory edema and improve sore Micro-circulation,promoting accelerated growth and granulation wound healing;Kushen of anti-allergic,anti-itching, anti-virus and anti-fungal and bacterial effectiveness;aloe not only has antibacterial effects,but also is an excellent natural skin moisturizing agent and nutrition agent,a skin care cosmetic function.Five are compatible not only with anti-inflammatory, antiseptic,antipruritic,sebaceous excretion open to prevent the effectiveness of secondary infection,and to kill and pityrosporum of Propionibacterium acnes bacteria spores and insects and mites in addition to skin care cosmetic effect.CDP clinical long-term topical treatment of acne,but found no good effect greater toxicity.But CDP will be the basis of traditional Chinese medicine and external mask,cream or gel for the treatment of acne combination has failed,the CDP clinical application to be combined with modern preparation techniques continue to study,no off-the-shelf product applications,not on the side a systematic pHarmacological and toxicological studies also have not conducted experimental study,therefore,the effective prescription on the basis of traditional Chinese medicine,will rule on the drug preparation and integration of advanced modern technology,research and development,a CDP drug facial mask,and CDP drug facial mask experiments and clinical research.The main issue in three parts:The first part is the CDP Preparation of the second part of the observation CDP film experimental rabbit ears acne;the third part is a double-blind,randomized controlled methods CDP unusual film treatment a clinical study of acne.ChapterⅠCDP drug facial mask Preparation and Quality ControlObjective:To study the CDP drug facial mask and the preparation of the establishment of quality standards.Methods:We will Kushen,rhubarb,aloes,in accordance with the prescription of PHellodendron the first time plus 10 times the amount of water and decocting two hours;second and eight times the volume of water and decocting 1.0 hours,filtration, the merger filtrate,pressurized enrichment the relative density of 1.2 g 20 drug-paste. Another admitted Monostearate Mannuronicate 2.8 g 16-18 alcohol 3.0 g,3.0 g liquid paraffin,stearyl alcohol ether -2 1.0g,1.0g stearyl ether -2 in 85℃fully mixing melted,and Homogenization of the oil phase;from disodium EDTA 0.05 g and 53.85g deionized water,stirring at 90℃fully melted,and homogenization produced water.Then join the aqueous phase of the oil by the same direction to mechanical agitation uniform completely emulsified in 75℃by adding 8.0 g glycerin,propylene glycol 2.0 g,1.0 g titanium dioxide,talc 0.5 g,5.0 g sulfur sublimation,ointment 20.0g,menthol alcohols such as full mixing 0.2 g,50℃lemon grass flavor by adding 0.2 g and 0.2 g preservatives Di United States,continue to stir can be cooled to room temperature.Then PH value of cold and heat,such as quality inspection.Results:The detection of soil samples show a semi-mobile-yellow uniform paste appearance,and no precipitation drug crystallization and found no stratification, and the control sample without distinction.Conclusion:This experimental study of the CDP by the appearance of drug mask cream color uniform for the semi-mobile paste,lemon fragrance maker to talk, meet the required sensory indicator.25℃pH value averaged 5.84,in line with the provisions of PH value of 4.0 to 8.5 range,respectively(40±1)℃24h and maintain (-5～-10)℃for 24 h,and returned to room temperature after pre-test significant difference between the physical and chemical indicators also consistent with the requirements.Through this experimental study,we investigated the quality of the preparation,access to the shape and PH value than ideal CDP drug facial mask extract,in order to further enhance its quality and stability laid a certain foundation.ChapterⅡCDP drug facial mask experimental rabbit ears on the impact of acneObjective:To observe the effect of CDP drug facial mask on acne model of rabbit’s ears.Methods:Oleic acid was applied on experimental rabbit’s ears(16 New Zealand white pure strain Rabbits) to establish the acne model of rabbit’s ears.The Oleic acid was smeared at 2 cm×2 cm opening site inside left and right ear of rabbit with 0.5 ml once per day for 3 successive weeks.The 21st day visual observation and takes the domestic rabbit right ear to spread the medicine place skin biopsy,10%formalin solution fixed,paraffin-embedded,sliced,HE - eosin,in the light histological changes were observed.The rabbits were randomly divided into treatment group and control group.The rabbits in treatment group were smeared with CDP drug facial mask 2ml once per day for 2 successive weeks.And the CDP drug facial mask was washing-out in 30 minutes.The rabbits in control group were smeared with tretinoin cream 1ml once per day.The 14st day visual observation and takes the domestic rabbit left ear to spread the medicine place skin biopsy.Results:Two weeks after smearing CDP drug facial mask in experimental group, it was observed that spline in local hair follicle was decreased,hair follicle shaped in points and incisure was leaved after abscission of local spline,and papules were relived.Histological observation manifested that thickness of cuticle was relieved, inflammatory cells of corium was reduced,but opening if hair follicle was expanded lightly and a new rarefaction was filled in.The acne symptom had been improved remarkably in treatment group smearing with CDP drug facial mask,and the difference of two groups has significant meaning(P＜0.05).Conclusion:Oleic acid was applied on experimental rabbit’s ears to establish the acne model of rabbit’s ears,CDP drug facial mask has anti-drug film follicle epithelium hyperkeratosis,reduce skin thickening and inhibition of the inflammatory response role.ChapterⅢCDP drug facial mask treatment acne clinical curative effect observationObjective:To observes the CDP drug facial mask treatment acne the clinical curative effect.Methods:122 patients with a randomized selected cases,the test group(group A) and the positive control group(group B) and the control group(group C),in which 41 patients in group A,group C,40 patients in group B.CDP drug test group used facial mask paste Tu affected area,once a day,30 minutes after the water washed away.The control group of drug use CDP to Face Mask paste matrix affected area, once a day,30 minutes after the water washed away.Positive control group with peacekeeping Aminovite vitamin E cream to Face the affected area,once a day,30 minutes after the water washed away.Four weeks for a course of treatment, respectively,before treatment,treatment one week,two weeks and the treatment of acne symptoms for four weeks points to observe and record the improvement of the skin lesions,truthfully filled out effect of form,before and after treatment photographic record,and records may occur Adverse reactions,and efficacy and safety evaluation.Results:three groups of acne vulgaris of the efficacy results show that the efficiency of the test group were 80.5%for clinical effect than external dimension Aminovite Vitamin E Cream 65.0%,in effect between the two groups is statistically not significant difference(P＞0.05).CDP drug facial mask group and the group of comparison matrix there was a significant difference(P＜0.05).Conclusion:CDP drug facial mask of acne vulgaris with the precise effect,and no apparent side effects.