Study On The Immunological Mechanism Of Recurrent Abdominal Pain And Food Intolerance In Children

ObjectiveTo explore the immunological mechanism of recurrent abdominal pain and food intolerance in children.Method55 cases of children with RAP as the observation group and 50 cases of medical healthy children as control group.Laboratory testing serum levels of specific IgG and IgE,observation with white blood cell count,eosinophil count,and C-reactive protein;Recurrent abdominal pain clinical manifestations and related factors.Compare the two groups of children FI and distribution of FA and the effect after the treatment,analysis the correlation between FI/FA and RAP of immune pathogenesis research.ResultTo compared two groups of children in FI situation,in the top three food intolerance were milk(67.27% vs 18.00%),followed by eggs(50.91% vs 16.00%),and the cod(41.82% vs 10.00%),but the observation group with intolerance rate is significantly higher than control group in children(chi-square = 25.830,P = 0.000;chi-square = 14.166,P =0.000;chi-square = 13.559,P = 0.000).The remaining intolerance food situation is found,observation group of children for corn,shrimp,crab,mushroom and soy and other five kinds of food intolerance rate is significantly higher than control group in children(P <0.05),chicken,beef,pork,rice,tomatoes and two groups of wheat intolerance was no statistical difference(P > 0.05).Children with recurrent abdominal pain as the main clinical manifestations of nausea,vomiting,abdominal pain,abdominal distension and anorexia,etc.,which all children appear on the abdomen or the surrounding area of discomfort and pain.Diet can relieve abdominal pain.Compare two groups of children FI species distribution,observation group with a food intolerance(12.73% vs 8.00%),two kinds of food intolerance(38.18% vs 10.00%),three or more food intolerance ratio are higher than the control group(16.36% vs 16.36%)children,compared the statistical difference between groups(Z =-5.072,P = 0.000).Through the research to detect allergen specific antibody IgE and IgG positive results found,Food intolerance IgG antibody positive 40 cases(72.7%),Specific IgE antibody positive 28 cases(50.9%),IgG and IgE antibody was 12 cases(21.8%)at the same time,All negatie in 2 cases(3.6%).Compared with different gender,age,weight,white blood cells,eosinophils and C-reactive protein RAP with relevance to the FI.FI detection in children with leukocytosis in 34 cases(80.95%),white blood cells is significantly higher than normal children with the FI detection rate of 23.08%,compared with the two groups statistically(P < 0.001).In addition,FI detection in children with increased eosinophils,25cases(80.65%),C-reactive protein increased FI detection in children with 31 cases(81.58%),rate of FI children were significantly higher than the normal 50.00% to 35.29%,comparing the two groups were statistically difference(chi-square = 5.770,P = 0.016;chi-square = 11.429,P = 0.001).Children with different gender,age and weight are not found in FI detection rate difference(P > 0.05).According to the results of single factor analysis,the white blood cells,eosinophils and C-reactive protein is increased as the independent variables,FI as the dependent variable for Logistic stepwise regression analysis.Results show that the factors related to RAP with FI include: white blood cells,eosinophils and C-reactive protein increased.Leukocytosis,FI detection increased risk,OR and 95% CI 2.962(1.907,1.907);Increased eosinophils,FI detection increased risk,OR and 95% CI 2.009(1.099,1.099);C-reactive protein increased,FI detection increased risk,OR and 95% CI 1.389(1.134,1.134).Recurrent abdominal pain reliever can avoid food intolerance,Through the study of the diet of patients with intolerance food around found after treatment,the longer the treatment time,the better effect,if again to eat food intolerance illness will relapse.ConclusionFI is also thought to be one of the important reasonsof the RAP in dhildren.RAP with FI related factors are: increased CRP,white blood cells and eosinophils.Through a reasonable diet to avoid,you can cure or relieve abdominal pain symptoms.