The Changes Of Plasma Motilin , Substance P And Psychological Factors In Children With Functional Recurrent Abdominal Pain

Background:Children with recurrent abdominal pain (recurreut abdominal pain, RAP) is common in clinical, especially functional recurrent abdominal pain.Functional somatic symptoms of functional abdominal pain, one can not refer to any organic disease to explain the non-specific physical symptoms, or one can not be completely explained by the medical knowledge, or the severity of their symptoms and medical examination does not match.In such cases, clinicians often feel difficult to carry out some of the unnecessary additional tests, increasing, and economic burden. Often given to children with antispasmodic agents, probiotics and other long-term conventional treatment, poor efficacy, which led to anxious parents and children with mental stress, and affect the normal life of children and learning. In recent years, functional recurrent abdominal pain has caused a lot of attention pediatrician, reported the information display on the cause of abdominal pain in children may be related to their personality, mood disorders (anxiety, depression), physiological and environmental, gastrointestinal hormones (MTL, SP ) the interaction of factors such as secretion disorder.Objectives:①To investigate the function of children with recurrent abdominal pain in plasma motilin (MTL), P substance (SP) levels and the disease.②At the same time function in children with recurrent abdominal pain and normal healthy children self-rating depression scale (SDS) and self-rating anxiety scale (SAS) questionnaire, to explore relevance in mood disorders and functional recurrent abdominal pain and the impact of mood disorders for the disease.Methods:①Detected by radioimmunoassay method in 50 cases of recurrent abdominal pain in children (study group) and 30 normal healthy children (control group) of fasting plasma MTL, SP were determined.②SDS and SAS to take psychological tests measuring table.Results:①Function in children with recurrent abdominal pain group MTL was 273.31±16.38 pg / ml, SP was 52.92±12.29pg/ml; control group, MTL was 225.46± 16.56pg/ml, SP was 33.14±8.15 pg / ml. Function in children with recurrent abdominal pain in plasma MTL, SP content compared with the control group mean increased significantly (P <0.05).②Function in children with recurrent abdominal pain group average score of SAS 54.37±9.56, significantly higher than asymptomatic, there are differences in changes (P <0.05). The average SDS score was 55.42±10.31, compared with the asymptomatic group differences in changes (P <0.05).Conclusions:①Function in children with recurrent abdominal pain in the body there MTL, SP secretion disorders and anxiety and depression disorders, indicating that children with functional recurrent abdominal pain may be related to MTL, SP, and increased levels of emotional disorders are closely related.②Clinically by MTL, SP analogues, blockers and psychological counseling, to diagnosis and treatment of functional recurrent abdominal pain, and thus alleviate the symptoms and psychological stress in children.