Study On The Relationship Between Phlegm Stasis Obstruction Syndrone And Subclinical Atherosclerosis In Rheumatoid Arthritis

Objective:In this study,investigate the relationship between the syndrome of phlegm stasis obstruction and the incidence of subclinical atherosclerosis in rheumatoid arthritis,and correlation between phlegm and blood stasis score and intima media thickness of internal carotid artery,in order to provide a more objective theoretical basis for the prevention and treatment of rheumatoid arthritis with atherosclerosis,fully excavate the advantage of TCM in the preventing and treating of Rheumatoid Arthritis patients with Atherosclerosis.Methods:Collect 90 cases of rheumatoid arthritis hospitalized from January 2017 to March 2018 in Department of Rheumatology,Xiamen traditional Chinese Medicine Hospital,Fujian University of traditional Chinese Medicine,the syndrome of phlegm and stasis obstruction:a report of 45 cases,45 cases of non-phlegm and stasis obstruction.According to the relevant diagnostic criteria,including the criteria,exclusion criteria,collect the patient's four diagnosis of traditional Chinese medicine data,TCM syndrome differentiation;The general data were recorded,including age,sex,height,weight,body mass index,blood pressure,blood lipid,blood glucose,liver function,renal function,rheumatoid factor,anti ccp antibody,erythrocyte sedimentation rate c reactive protein and so on.Bilateral carotid intima-media thickness and atherosclerotic plaque as subclinical indexes of atherosclerosis.Comparison of the incidence of subclinical atherosclerosis in rheumatoid arthritis patients with phlegm and stasis obstruction syndrome and non-phlegm stasis obstruction syndrome,analysis of correlation between phlegm and blood stasis score and carotid intima-media thickness in patients with rheumatoid arthritis.Result:1.The results showed that there was significant difference between the study group and the control group in the DAS28 score by the rank-sum test(p<0.05),the study group and the control group in the CRP by the rank-sum test(p<0.05).2.The significant correlation between CIMT and CRP in the study group and the control group(P<0.05),which suggested that the CRP of the patients was higher than that of the control group(P<0.05).There was significant correlation between CIMT and DAS28 score in the patients with thicker CIMT(P<0.05),indicating that the higher theDAS28 score was,the higher of the DAS-28 score was.3.The thicker the carotid intima and the detectable rate of the plaque in the study group were 68%and 57%,the thickness of the carotid artery was 31%and the detectable rate of the plaque was 29%in the control group.The CIMT of the study group was significantly thicker than that of the control group.4.There was a significant correlation between phlegm and blood stasis score and CIMT in patients with CIMT.Conclusion:1.The disease activity of RA patients with phlegm stasis obstruction syndrome is higher than that of non-phlegm stasis obstruction syndrome.2.The CIMT of RA patients is related to disease activity,and the disease activity is higher than that of non-phlegm stagnation syndrome patients.3.The higher the CIMT was,the higher the CIMT was in RA patients with phlegm stasis obstruction syndrome than in those without phlegm stasis obstruction syndrome,and the higher the plaque detection rate was,the positive correlation was found between the phlegm and blood stasis score of RA patients and the thickness of carotid intima media.It is suggested that phlegm and stasis obstruction plays an important role in RA complicated with AS,and the risk of AS is higher in RA patients with phlegm and stasis obstruction syndrome.