Clinical Study On The Treatment Of Rheumatoid Arthritis Of Phlegm-Stasis-Bi Blocking Type With Chubi No.1 Prescription And Western Medicine

Objective:To observe the clinical efficacy of Chubi No.1Prescription combined with western medicine in the treatment of rheumatoid arthritis(RA)with phlegm and blood stasis obstruction.Methods:From March 30,2017 to October 30,2018,this study selected 60 patients in the first affiliated hospital of Guangxi University of Traditional Chinese Medicine and 60 patients in the outpatient and inpatient phlegm paralysis type RA.The randomized method was used to divide 60 patients into 1:1 treatment group.30 cases in each group.The control group was given oral methotrexate(MTX)+ lefluronide(LEF)+melloxacone tablets,and the treatment group was given a 12-week course of treatment based on the control group.Chinese medicine syndromes scores,RA clinical activity score(DAS28),HAQ-DI,VAS,CRP,RF,and blood sink were selected for two groups of patients.ESR)observed and compared the incidence of adverse reactions in the two groups of patients to evaluate the clinical effect of Debiao 1 and Western medicine in the treatment of phlegm and paralysis blocking RA.Results:(1)comparison of the total curative effect between the two groups: in terms of the curative effect of TCM syndromes,the total curative effect of the treatment group was 93.3%,while that of the control group was 70%,the difference was statistically significant(p<0.05),and the treatment group was superior to the control group.In terms of curative effect of disease activity degree,the total curative effect of thetreatment group was 90%,and that of the control group was 73%,the difference was statistically significant(p<0.05),and the treatment group was superior to the control group.(2)Comparison of symptoms and signs between the two groups: after treatment,the number of joint tenderness and joint swelling in both groups was reduced(p < 0.05),and the treatment group had better efficacy than the control group(p<0.05).(3)comparison of TCM syndrome points between the two groups: the differences in TCM syndrome points,joint swelling,joint pain,joint tenderness,joint disadvantage and morning stiffness before and after treatment between the two groups were statistically significant(p<0.05),and both groups had curative effect.The improvement of the treatment group was better than that of the control group(p<0.05).(4)comparison of laboratory indicators between the two groups: both groups showed statistically significant difference in CRP,ESR and RF decrease after treatment(p<0.05),and the treatment group was superior to the control group in reducing CRP and ESR(p<0.05).There was no difference in RF between the two groups(p<0.05).(5)comparison of disease score scales between the two groups: VAS score,DAS28 score and haq-di score of the two groups after treatment were significantly improved(p<0.05),and the treatment group had better efficacy than the control group(p<0.05).(6)comparison of adverse reactions between the twothe incidence of adverse reactions in the treatment group was 3.33%,and the incidence of adverse reactions in the control group was 13.3%.Statistical analysis showed that the difference between the two groups was not statistically significant(p<0.05).Conclusion: In addition,the combination of No.1 side and Western medicine can effectively relieve the condition of patients with phlegmstasis and paralytic RA,and it is effective in clinical manifestations,laboratory indicators,disease activity score,and quality of life.