Clinical Study On Yunshao Paan Decoction In Treating Non-motor Symptoms Of Parkinson's Disease

Purpose:To observe the clinical efficacy on Yunshao Paan decoction in treating non-motor symptoms of Parkinson's disease.For explore the theoretical basis of treating PDNMS by guiding with the "warm kidney Yang,nourishing the liver blood "therapy.Methods:A total of 68 patients of PD(out of 6 cases)were enrolled during the study period.The patients were divided into treatment group(n=32,treated by both western medicine and Yunshao Paan decoction)and control group(n=30,only treated by western medicine).The two groups were compared with clinical efficacy on non-motor symptom scale(NMSS),Parkinson's disease questionnaire-39(PDQ-39),Unified Parkinson Disease Rating Scale ?(UPDRS ?),Levodopa equivalents doses(LDE)and Hoehn-Yahr(H-Y)grading scale after treating 2 months.Results:? Compared with two groups of NMSS scores after the treatment,the total clinical effective rate of NMSS was 62.50%in treatment group and 13.33%in control group.The effective rate of NMSS in treating group was significant higher than control group,the difference was statistically significant between the two groups(P<0.01).The NMSS scores decreasing was statistically significant in treatment group after treating(P<0.01);while the control group was insignificantly(P>0.05).Compared with the two groups of NMSS scores change after treating,there was significant difference between the two groups(P<0.05).?Compared with two groups of PDQ-39 scores after the treatment,the total clinical effective rate of PDQ-39 was 46.88%in treatment group and 10.00%in control group.The effective rate of PDQ-39 in treating group was significant higher than control group,the difference was statistically significant between the two groups(P<0.01).The PDQ-39 scores decreasing was statistically significant in treatment group after treating(P<0.01);while the control group was insignificantly(P>0.05).Compared with the two groups of PDQ-39 scores change after treating,there was significant difference between the two groups(P<0.05).?Compared with the Symptom severity distribution changes of NMSS in treatment group after treatment,the difference of the gastrointestinal symptoms and urination symptoms is statistically significant(P<0.05).?There was no statistically significant difference(P>0.05)between the two groups of the UPDRS ? score,LDE and H-Y grading scale.? Adverse reactions and safety analysis showed that there was no significant change about related monitoring indicators after treatment.Conclusion:? Yunshao Paan decoction can effectively improve the overall non-motor symptoms and the quality of life of PD patients,of which to improve the gastrointestinal symptoms and urinary conditions best.?There is no significant advantage by using Yunshao Paan decoction to treat the motor symptoms,the dose of levodopa and H-Y grading scale.?There is no adverse events by using Yunshao Paan decoction in the whole progress of treatment course,indicating that it is safety for clinical use.