Study On The Mechanism Of Shugan Jiangzhi Granule In The Treatment Of Nonalcoholic Steatohepatitis (Liver Depression And Spleen Deficiency Syndrome)

Objective: To observe the clinical efficacy of Shugan Jiangzhi granule in the treatment of non-alcoholic steatohepatitis,and to explore the mechanism of Shugan Jiangzhi granule in the treatment of non-alcoholic steatohepatitis,so as to provide a theoretical basis for clinical application.Methods: A random data sheet generation and grouping method is used for grouping,and packet labels are placed in sealed envelopes.When entering the group,the envelopes are extracted in order,and the corresponding groups and treatment schemes are given in accordance with the label number.80 patients with nonalcoholic steatohepatitis who met the inclusion criteria were divided into treatment group(Shugan Jiangzhi granule combined with Polyene Phosphatidylcholine Capsules)and control group(Polyene Phosphatidylcholine Capsules),40 cases in each group.Treatment group and control group were quit alcohol,low sugar low-fat low calorie and high cellulose diet during treatment,reasonable exercise(control every step in the6000 step,left and right)before and after treatment were observed:(1)liver function: alanine aminotransferase(ALT)and aspartate aminotransferase(AST);(2)blood lipids: Total cholesterol(TC),triglyceride(TG);(3)score of TCM syndrome;(4)insulin resistance index;(5)superoxide dismutase(SOD);(6)imaging(ultrasound and FibroScan);(7)security.Result:1.Liver function response: after treatment,the ALT and AST values of the two groups were significantly decreased and the difference was significant(P<0.05).After treatment,there was a significant difference between the treatment group and the control group in the ALT value,P<0.05;there was no significant difference in AST between the two groups after treatment,P>0.05,and there was no statistical difference.2.Lipid response: after treatment,the TC and TG values of the two groups decreased significantly.There was a significant difference between the two groups after treatment compared with those before treatment(P<0.01).After treatment,the TC between the two groups was compared,P<0.05,with statistical difference.There was a significant difference in TG between the two groups after treatment,with statistical significance(P<0.05).3.TCM syndrome score: the total effective rate of the treatment group was86.5%,the total effective rate of the control group was 68.4%,and the treatment group was superior to the control group(P<0.05).4.Insulin resistance index: after treatment,the insulin resistance index of the two groups decreased significantly.After analysis,there was a significant difference between the two groups after treatment than before treatment(P<0.01).After treatment,the two groups were compared,P<0.05,withstatistical difference.5.Superoxide dismutase: after treatment,the two groups of patients with superoxide dismutase increased significantly.After analysis,there was a significant difference between the two groups after treatment than before treatment(P<0.01).After treatment,the two groups were compared,P<0.05,with statistical difference.6.Imaging response:6.1 Ultrasound imaging response: To compare the treatment group before and after treatment,the Fisher precision correction P<0.05,with statistical difference;the control group before and after treatment,the Fisher precision correction,P<0.05,with statistical difference;the treatment group and control group in the total efficiency compared with significant difference(P<0.05),the treatment group was significantly better than the control group.6.2 FibroScan grade response: To compare the treatment group before and after treatment,the Fisher precision correction P<0.05,with statistical difference;the control group before and after treatment by Fisher the accurate correction P<0.05,with statistical difference;the treatment group and control group in the total efficiency compared with significant difference(P<0.05),the treatment group was significantly better than the control group.7.Security review: before and after treatment,the two groups of patientshad obvious good reaction,and the safety was good.Conclusion: 1.Shugan Jiangzhi granule combined with Polyene Phosphatidylcholine Capsules Polyene Phosphatidylcholine Capsules compared with the single clinical symptoms improved by NASH patients,TCM syndrome scores decreased significantly,has good regulating effect on liver function,blood lipids,liver ultrasound numerical classification and FibroScan decreased obviously,good safety.2.Through the observation of in the early stage of experimental study,found that Shugan Jiangzhi granule could significantly reduce the patient's insulin resistance index and increase the content of superoxide dismutase from disease,its mechanism and treatment of NASH may improve insulin resistance and oxidative stress related improvement.