Clinical Observation Of Jiangzhi Sanren Decoction In Treating Non-alcoholic Steatohepatitis With Internal Damp-heat Type

Purpose: Nonalcoholic fatty liver disease is a metabolic stress-induced liver injury closely related to insulin resistance and genetic susceptibility.Hepatic macrobubble fat becomes its main pathological change,and it is clinically divided into simple ones according to the degree of disease.Fatty liver disease,steatohepatitis and cirrhosis,the susceptibility factors are poor lifestyle,abnormal body metabolic syndrome,such as high-energy diet,sedentary movement,obesity,type 2 diabetes,hyperlipidemia,etc.factor.The incidence of nonalcoholic fatty liver in adults in China is about 15%-25%,which has become the most common liver disease in China.It can cause liver cell damage.If it is not treated,it can develop into liver cirrhosis and even liver cancer.,causing serious harm.At present,Western medicine treatment of the disease emphasizes the change of bad habits including exercise,diet to reduce weight loss and insulin resistance,as well as the application of drugs such as liver-protecting drugs and lipid-lowering drugs.However,its efficacy has not been effectively confirmed,that is,the lack of specific therapeutic drugs,so Finding safe and effective prescriptions from traditional Chinese medicine has great guiding role and clinical therapeutic value.Jiangzhi Sanren Decoction is the experience of Professor Wu Bailing through many years of clinical experience in the treatment of this disease.This article is the clinical efficacy of the treatment of non-alcoholic fatty liver disease.Method: The 60 subjects who were randomly selected for diagnosis were in compliance with the non-alcoholic fatty liver diagnosis criteria in the Guidelines for Prevention and Treatment of Nonalcoholic Fatty Liver Diseases(2018 Update)and the Consensus Opinions of Chinese Medicine Consultation for Nonalcoholic Fatty Liver Disease(2017)The patients with symptoms of damp-heat intrinsic syndrome showed clinical symptoms of 60 patients with flank pain,general malaise,right upper quadrant,nausea and vomiting,and loss of appetite.They were randomly divided into control group and treatment group.There were no significant differences in the general conditions of age,gender,and TCM symptom scores among 30 people,and the two groups had comparative significance(P>0.05).The control group was treated with oral Yishanfu(polyene phosphatidylcholine)2 capsules,vitamin E 100 mg,3 times a day orally;the treatment group was treated with Jiangzhi Sanren Decoction,1 day,a total of 400 ml of liquid medicine,morning and evening 2 times of service,2 groups of treatment time are 3 months,during treatment,patients with sputum changed bad habits,appropriate physical exercise,reduce high-energy diet intake,alcohol consumption,and drugs that affect the clinical observation indicators.After treatment,the changes of TCM syndrome scores,liver function,blood lipids,body mass index,interleukin-6 and ultrasonography were observed before and after treatment.The adverse reactions caused by drugs were observed and compared.Results: 1.The total effective rate of the two groups was compared: 86.7% in the treatment group and 63.3% in the control group.There was a significant difference in the clinical efficacy between the two groups(P<0.05).2.Comparison of TCM syndrome scores between the two groups: After treatment,there was significant difference between the treatment group and the control group(P<0.05);there were also differences between the two groups before and after treatment(P<0.05).3.Comparison of two groups of indicators: After treatment,blood lipids(TG),BMI,and interleukin-6 were significantly different(P<0.05).There were no liver function(ALT,AST,GGT)and body mass index(BMI)in the two groups.Significant difference(P > 0.05).4.Ultrasound examination: After treatment,liver imaging changes were compared,and there were differences between the two groups(P<0.05).Conclusion:The results of this clinical study show that: Jiangzhi Sanren Decoction is better than western medicine in treating non-alcoholic fatty liver.Jiangzhi Sanren Decoction relieves symptoms,lowers triglycerides,lowers body mass index,lowers interleukin-6,reduces lipid oxidation,and reduces The degree of liver fat changes is more advantageous,and its curative effect is exact,with no toxic side effects.