| Objective: To explore the efficacy and safety of Zhiju Decoction in the treatment of mild acute alcohol poisoning wine toxin syndrome,and give play to the advantages of TCM treatment of acute alcoholism,so as to lay a clinical foundation for the development of new drugs.Methods: From March 2017 to December 2017,90 cases of mild acute alcoholism randomly selected from the emergency department of Yunnan traditional Chinese medicine hospital were selected as the research object,and the efficacy observation and safety analysis were carried out in the emergency clinic.All patients had a history of high alcohol(100ml~200ml)drinking in front of the hospital,and30~60min came to hospital after drinking.The patients were treated with 3 different schemes.The patients were divided into 3 groups by random grouping digital tables,30 people in each group,which were divided into the glucose group(Control group 1),Yitang B1 group(Control group 2)and the Zhiju Decoction group.All patients are treated under strict vital signs monitoring.the Zhiju Decoction group oral configured Zhiju Decoction 250 ml,glucose group oral 10% glucose 250 ml,Yitang B1 group Give10% glucose 250ml+10% Potassium Chloride Injection 7ml+ Insulin injection 7iu intravenous drip,while oral 5mg vitamin B1 tablets at the same time 2 tablets.The symptom score and breath alcohol concentration of three groups were recorded for60 min,120min and 150 min.According to the change of integral and breath alcohol concentration,the curative effect was evaluated and statistically analyzed.To observe the safety and adverse reactions.Results:(1)In the treatment of 60 min,the syndrome score was compared,and4 the difference between the three groups compared with those before treatment was statistically significant(p < 0.01),and there was no significant difference between the groups(p>0.05).Efficacy rate comparison,There was no statistically significant difference between the three groups(p>0.05).There was no statistically significant difference between expiratory alcohol concentration and pretreatment and group comparison.(2)In the treatment of 120 min,the syndrome score was compared,and the difference between the three groups compared with those before treatment was statistically significant(p < 0.01),comparison between groups,there was no significant difference between the Zhiju Decoction group and the Yitang B1 group(p>0.05),the Zhiju Decoction group was better than the glucose group(p < 0.01),and the Yitang B1 group was better than the glucose group(p < 0.05),which was statistically significant.Efficacy rate comparison,definite the Zhiju Decoction group compared with the Yitang B1 group there was no statistically significant difference(p > 0.0167),definite the Zhiju Decoction group is better than glucose group(p < 0.0167),the Yitang B1 group is better than glucose group(p < 0.0167),the difference was statistically significant.Breath alcohol concentration,definite the Zhiju Decoction group and the Yitang B1 group compared with before treatment differences were statistically significant(p < 0.01),glucose group compared with before treatment has no obvious difference(p > 0.05),there was no statistically significant differences in between three groups(p > 0.05).(3)In the treatment of 150 min,the syndrome score was compared,and the difference between the three groups compared with those before treatment was statistically significant(p < 0.01).Comparison between groups,definite the Zhiju Decoction group is better than that of Yitang B1 group(p < 0.0167),definite the Zhiju Decoction group is better than glucose group(p < 0.0167),the Yitang B1 group is better than glucose group(p < 0.0167),the difference was statistically significant.Efficacy rate comparison,the Zhiju Decoction group was superior to the Yitang B1 group(p < 0.0167)and the glucose group(p < 0.0167),and the Yi Tang B1 group was better than the glucose group(p < 0.0167).Breath alcoholconcentration,three groups was compared with the difference was statistically significant(p < 0.01),definite Zhiju Decoction group is better than that of Yitang B1group(p < 0.01)and glucose group(p < 0.01),Yitang B1 group compared with the glucose group there was no statistically significant difference(p > 0.05).(4)Safety evaluation: There was no obvious abnormality in blood routine,urine routine,liver and kidney function,blood glucose examination before and after treatment in all three groups of patients.No adverse reactions and toxic side effects occurred in all subjects during the clinical trial.Conclusion: Definite Zhiju Decoction group more Yitang B1 group and glucose group can improve more mild acute alcohol intoxication these intrinsic syndrome in patients with symptoms and signs,and can significantly reduce the breath alcohol concentration,the clinical curative effect and no obvious adverse reaction,safety and reliable. |
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