| Objective:By observing the clinical trial of huotan tongluo jiedu recipe on acute coronary syndrome(phlegm stasis tongluo jiedu recipe),the clinical therapeutic effect of huotan tongluo jiedu recipe on acute coronary syndrome(phlegm stasis tongdu recipe)was further clarified,and the therapeutic effect was evaluated,providing ideas for TCM treatment of acute coronary syndrome.Methods:According to the inclusion criteria and exclusion criteria,72 patients who were clearly diagnosed as acute coronary syndrome in the department of cardiology,affiliated hospital of changchun university of traditional Chinese medicine were screened,and the clinical syndrome diagnosis was in line with the criteria of sputum deposition and toxic accumulation.The age range was 18-75 years old for both men and women.Random number coding was used to randomly group 36 cases in each test group and control group.For all the selected patients were standardized treatment of western medicine(aspirin,for Greg lowe,statin calcium tablet,rui shu.Ramipril and other drug treatment),group norms to western medicine treatment and clear phlegm t2dm detoxification treatment(Fried juice 300 ml water,150 ml each time,two oral)and control group were given western medicine treatment.At the same time,combined with the patient's own complications,the corresponding drugs were given.The course of treatment was 4 weeks in total.The scores of TCM symptoms before and after treatment,Seattle angina scale,quality of life,and ecg efficacy of the two groups were observed,and statistical analysis was conducted by combining and applying X~2 test and t test.Results:(1)age,gender,course of disease,disease type,risk factors,TCM symptom score and distribution before treatment were compared between the experimental group and the control group,with P>0.05,which was not statistically significant and comparable.(2)In terms of the curative effect of angina pectoris,there was a significant improvement in the curative effect between the two groups after the treatment(P<0.05).The difference between the two groups was statistically significant(P<0.05),it showed that the improvement of experimental group was more obvious than that of control group.(3)in terms of quality of life,both the experimental group and the control group showed significant improvement in quality of life after treatment compared with before treatment,with P values less than 0.05.The comparison between the two groups after treatment showed that the mean scores of all aspects in the experimental group were significantly higher than those in the control group,indicating that the efficacy of the experimental group was more obvious.(4)in terms of TCM symptoms,Wilcoxon test was used to analyze the main symptoms between the experimental group and the control group.In the case of concurrent symptoms of TCM symptoms between the experimental group and the control group,the Wilcoxon test(Wilcoxon test)analysis of two related samples showed that there was a statistical difference in the comparison of symptoms before and after treatment in the experimental group.After treatment,the rank-sum test(mann-whitney U test)was used to compare the scores.The results showed that the levels of all indexes in the experimental group were significantly lower than those in the control group,indicating that the experimental group had better effects.(5)Judge the curative effect according to recovery situation in the symptoms of traditional Chinese medicine,angina pectoris and electrocardiogram three aspects.On the curative effect of symptoms of traditional Chinese medicine,the total effective rate was 91.9%in the experimental group and 83.3%in the control group.On the curative effect of angina pectoris,the total effective rate was 94.4%in the experimental group and 86.1%in the control group.On the curative effect of electrocardiogram,the total effective rate was91.7%in the test group and 80.6%in the control group.Therefore,the analysis showed that the curative effect of the experimental group was significantly better than that of the control group,P<0.05,the total effective rate of test group was higher than that of control group.(6)In the clinical trial,there were no deaths,hospital transfers or CABG surgeries in the control group or the experimental group,but 3 patients in the control group underwent PCI.PCI was performed in one of the trial groups.The incidence of cardiovascular events in the two groups within two weeks after treatment was 8.3%in the control group and 2.7%in the experimental group,respectively(note:patients should agree and sign an informed consent to undergo PCI surgery due to cardiovascular events in the two weeks after treatment).The comparison of PCI between the two groups by Fisher's exact test showed that P>0.05 was not statistically significant.Conclusion:1.Huotan tongluo jie du prescription has obvious clinical effect in the treatment of acute coronary syndrome with phlegm deposition and toxic accumulation,and the patient has no adverse reactions.2.Huotan tong luo detoxification prescription has been significantly improved in the treatment of TCM symptoms and quality of life of acute coronary syndrome with phlegm deposition and toxin accumulation,and has the advantages of good effect,few side effects and low price.It is worth to be promoted clinically and has certain clinical application value. |
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