Clinical Study On The Treatment Of Acute Alcoholism In Non Coma Period By Shuang Ge Jie Jiu Decoction

ObjectiveBy observing the efficacy and safety of Shuang ge jiejiu prescription in the treatment of acute alcoholism,this paper discusses the pathogenesis of this disease and provides a clinical basis for the treatment of acute alcoholism with shuangge jiejiu prescription.MethodsSelection according to the inclusion criteria in December 2018-December 2019 clinic in our hospital emergency outpatient 60 cases of coma period of acute alcohol poisoning patients,using SPSS random number group were divided into treatment group and control group 30 cases,all patients life monitoring cases treatment,the treatment group oral preparation of double ge party(warm water)250 ml of adjustable oral therapy,the control group was given 5% glucose and sodium chloride injection250ml+vitamin injection 10ml+ vitamin B6 0.2gintravenous drip.The TCM syndrome score and expiratory alcohol concentration of the patients in the two groups were recorded at the time points of 60,120 and 150 min of treatment respectively.According to the score value and the changes of expiratory alcohol concentration,the efficacy and aging evaluation and statistical analysis were conducted,and the vital signs and adverse reactions of the patients in the two groups were observed.Result:1.Score calculation of TCM symptoms: there was a difference between the two groups before and after 60 min treatment(p < 0.01),and there was no significant difference between the two groups(p > 0.05).There was a significant difference between the two groups before and after 120 min treatment(p < 0.01),but no significant difference between the two groups(p > 0.05).There was a significant difference between the two groups before and after 150 min treatment(p < 0.01),and the treatment group was significantly higher than the control group(p < 0.01).2.TCM aging comparison: there was no significant difference between the two groups before and after 60 min treatment(p > 0.05);There was no significantdifference between the two groups in the treatment of 120(p > 0.05).There was a difference between the two groups within 150 min of treatment(p < 0.01),and the treatment group was superior to the control group(p < 0.01).3.Comparison of expiratory alcohol concentration: there was no significant difference between the two groups before and after 60 min treatment(p > 0.05).The comparison between the two groups before and after treatment in the 120 min treatment group was statistically significant(p < 0.01),while the comparison before and after treatment in the control group was not statistically significant(p >0.05).There was a difference between the two groups before and after 150 min treatment(p < 0.01),and the treatment group was significantly higher than the control group(p < 0.01).4.Safety evaluation: no obvious abnormalities were found in blood biochemistry,blood glucose and electrocardiogram before and after treatment in the two groups.Conclusion1.Both gexijiu prescription and the control group have achieved effective effects in the treatment of non-coma acute alcoholism.2.Compared with naloxone,the prescription of shuangkuijiu was more significant in the treatment of aging and the reduction of expiratory alcohol concentration.3.After the study,it is found that the formula has high clinical safety and good hangover cure effect,which can be further applied in the clinic.