Study On The Correlation Between Phlegm-heat Depression Of Pulmonary Distention And Serum SAA

Objective: this subject from the clinical characteristics of the traditional medicine syndrome differentiation of TCM and modern medicine theory as a starting point,combining with Serum amyloid protein A(Serum amyloid A,SAA)as the main test indicators,to observe the SAA in yu lung phlegm heat syndrome,Yang deficiency water flood the changes of the patients,supplemented by TCM symptom scores and clinical routine blood,color doppler echocardiography,pulmonary function,blood gas analysis and related inspection,type in the two lung Serum levels of SAA certificate and the change rule of between SAA and the correlation of two card type,provide certain reference for the clinical diagnosis and treatment of lung distension.Methods: In this project,a randomized parallel control observation method was adopted to include 45 cases of phlegm-heat depression and 45 cases of yang deficiency water,with a total of 90 cases.Based on clinical manifestations on admission to hospital,to assess the patient's main symptoms and clinical signs,and in the hospital the next day fasting venous blood collected in laboratory tests,including White Blood Cell(WBC),Neutrophilic Granulocyte Percent(NEUT%),high-sensitivity C-reactive protein(hs-CRP),Brain Natriuretic Peptide(BNP)and so on,in order to color doppler echocardiography,lung function,arterial blood gas analysis and color doppler echocardiography Pulmonary Arterial Pressure(PAP),Left Ventricular Ejection Fraction(LVEF)as observation indexes,lung function Forced expiratory volume in one second(FEV1/FVC),forced expiratory volume in one second percent predicted(FEV1%)as observation indexes of expected values,arterial blood gas analysis of Potential Of Hydrogen(PH value),Oxygen partial pressure(Pa O2),Partial pressure of carbon dioxide(Pa CO2)as observation indexes.The serum SAA level wasdetected by a double antibody sandwich enzyme-linked immunosorbent assay.To evaluate the difference and correlation between serum SAA and other clinical observation indicators in the two syndromes of lung distension and phlegm and yang-deficiency syndrome.Results:1.Serum SAA level comparison,between the two syndromes of phlegm heat syndrome group and yang deficiency water group,the difference was statistically significant(P<0.05).2.WBC,NEUT%,hs-CRP level were compared,the differences between the two syndromes of the phlegm thermo-depression and the Yang deficiency water were statistically significant(P<0.05)3.There were statistically significant differences in cough,phlegm,asthma,cyanosis and edema in the two syndromes of phlegm heat syndrome and yang deficiency water(P<0.05).4.Compared with BNP,there was a statistical significance in the BNP difference between the phlegm heat and yang-deficiency syndrome(P<0.05)5.the difference of PAP between the two syndromes of the phlegm heat and lung syndrome group and the yang-deficiency water pan syndrome group was statistically significant(P<0.05).The EF differences between the two syndromes of the phlegm,phlegm and lung syndrome groups were statistically significant(P<0.05).6.Arterial blood gas comparison,There was no significant difference in PH value between the two syndromes of phlegm fever and lung syndrome group and Yang deficiency water(P>0.05).There were statistically significant differences in Pa O2 and Pa CO2 between the two syndromes(P<0.05).7.In the phlegm heat syndrome group,SAA was positively correlated with WBC and was statistically significant(P<0.05).SAA and NEUT% were positively correlated with statistical significance(P<0.05).SAA was positively correlated with hs-CRP,with significant statistical significance(P<0.01).There was no correlation between SAA and WBC,NEUT%,hs-crp in the yang-deficiency water pan syndrome group(P>0.05).8.In the phlegm heat syndrome group,.SAA was positively correlated with cough score,which was statistically significant(P<0.05).SAA was positively correlated with sputum score,with significant statistical significance(P<0.01).There was no correlation between SAA and asthma,cyanosis and edema,no statistical significance(P>0.05).In the yang-deficiency water pan syndrome group,there was no correlation between SAA and cough,sputum,asthma,cyanosis and edema,all of which were not statistically significant(P>0.05).9.There was no correlation between SAA and EF and PAP in the two syndromes of phlegm heat syndrome group and Yang deficiency water pan syndrome group(P>0.05).There was no correlation between SAA and Pa O2 and Pa CO2 in the two syndromes of the phlegm-heat syndrome group and the Yang deficiency water pan syndrome group(P> 0.05).10.There was no correlation between BNP and cough,phlegm,asthma,cyanosis and edema in the phlegm and lung syndrome group(P>0.05).In the yang-deficiency water pan syndrome group,the BNP was positively correlated with the asthma score(P<0.05),BNP was positively correlated with cyanosis and edema,both of which had significant statistical significance(P<0.01).11.In the yang-deficiency water pan syndrome group,there was a negative correlation between BNP and EF(P<0.05).The correlation between BNP and PAP,was statistically significant(P<0.05).12.In the yang-deficiency water pan syndrome group,there was a negative correlation between BNP and Pa O2(P<0.05).The correlation between BNP and Pa CO2 was statistically significant(P<0.05).Conclusion:1.Serum SAA levels were significantly increased in lung swelling and phlegm,and with WBC,NEUT%,hs-CRP.The increase of SAA shows a rising trend,and SAA concentration can reflect the degree of infection of the disease.SAA may participate in the inflammatory reaction process of lung swelling and phlegm.2.Pulmonary distention of phlegm and phlegm,cough is heavier,and there is more phlegm.The higher the serum SAA,the more symptoms of cough and sputum,indicating that the more serious the infection in the phlegm,the heavier the cough and the more phlegm.3.Lung distension Yang deficiency in the water flood the serum BNP level significantly increased,with higher BNP,EF,Pa O2 gradually reduce,PAP,Pa CO2 gradually rise,prompt Yang deficiency water card may have different degrees of heart function decline and the ability to reduce to carry oxygen.4.Lung distension Yang deficiency water pan syndrome asthma,purple cyanosis,the degree of edema is more than phlegm.The higher the BNP,the greater the asthma,cyanosis and edema.