Lung Distension Common Type Three Certificates And The Correlation Of Serum ADPN,AQP-5

Objective:This topic from the modern medical theory and clinical characteristics of the traditional medicine of TCM syndrome differentiation,to detect the serum adiponectin(ADPN),water channel protein-5(AQP-5)in the lung and kidney deficiency syndrome and Yang deficiency of lung yu lung water pan syndrome,phlegm heat syndrome in patients with changes as the main content of observation.Supplemented by TCM symptom scores and clinical routine blood,heart colour to exceed,lung function and relevant inspection,explore serum ADPN,AQP-5 levels in the common lung change rule of the three syndrome types and ADPN,AQP-5,and the correlation of lung distension three syndrome types,for Chinese medicine clinical diagnosis and treatment of lung expansion to provide certain reference.Method:This topic design adopts the method of random parallel control obser vation,with cases included in the standard respectively in 30 cases of lung and kidney deficiency syndrome and Yang deficiency water pan 30 cases,phlegm heat yu lung card 30 cases,a total of 90 cases.According to clinical manifes tations on admission to hospital,evaluate the main symptoms and clinical signs,and on the second day of admission to abdominal blood related laboratory examinationin cluding White Blood Cell(WBC),neutrophil percentage(NEUT%),Brain Natriuretic Peptide(BNP)and so on,in order to cardiac color doppler,lung function,The heart of color doppler ultrasound select Right Ventricular end-diastolic Diameter(RVEDd),Pulmonary Artery Pressure(PAP)as observation indexes,lung function FEV1/FVC,FEV1 percentage of expected value,FVC percentage of expected value.Step with double antibody sandwich enzyme-linked immunosorbent method to detect serum ADPN,AQP-5 levels.Assessment of lung distension Yang deficiency water pan syndrome,lung and kidney deficiency syndrome,phlegm heat yu lung the symptom scores of the three kind of this syndrome,and collect the record three syndrome types in all kinds of auxiliary examination data.And three syndrome types of serum ADPN,AQP-5 and the auxiliary examination data,statistical analysis of symptom scores to explore serum ADPN,AQP-5,and related auxiliary examination data in the differences an d correlation of 3 card type.Result: 1.Serum levels of ADPN compare 3 card type,Comparison of Phlegm-heatDeficiency Syndrome and Yang-deficiency-Deficiency Syndrome and Lung-Kidn ey Deficiency Syndrome,There were statistically meaning difference(P<0.01);Comparison between Yang Deficiency Water Syndrome and Pulmonary Deficiency Syndrome,There is no statistically meaning difference(P>0.05).2.Serum levels of AQP-5 compare 3 card type,Yang deficiency water syndrome group were compared with lung and kidney qi deficiency syndrome group,phlegm-heat syndrome group,Differences had statistically meaning(P<0.05,0.01);Lung and kidney deficiency syndrome and phlegm heat yu lung group,there was no statistically meaning difference(P>0.05).3.Three types of cough,sputum,asthma,cyanosis score comparison,Yang deficiency syndrome group,lung and kidney qi deficiency syndrome group and phlegm heat syndrome group,the difference had statistical meaning(P<0.01);Yang deficiency water pan card group compared with lung and kidney deficiency syndrome group,The difference was not statistically meaning(P> 0.05).Comparison of three syndromes edema scores,Lung and kidney qi deficiency syndrome group,phlegm and heat syndrome group were compared with Yang deficiency water syndrome group,the differences had statistically meaning(P<0.01);Comparison of phlegm-heat-deficiency syndrome group and lung-kidney-qi deficiency syndrome group,the difference had no statistically meaning(P> 0.05).4.FEV1%predicted,FEV1/FVC,FVC%predicted were compared between the three syndromes,Differences had no statistical meaning(P>0.05).5.here was no statistically meaning difference between the three types of WBC count.Three proof NEUT% comparison,Yang deficiency syndrome group,lung and kidney qi deficiency syndrome group and phlegm heat syndrome group were compared,the difference had statistical meaning(P<0.01);Pulmonary and kidney qi deficiency syndrome group compared with Yang deficiency type syndrome group,there was no statistically meaning difference(P> 0.05).6.Three card type right ventricular end diastolic diameter type between the two pairs of comparison,the difference had statistical meanings(P< 0.01).7.Comparison of three card type pulmonary artery pressure,Phlegm and heat syndrome group,lung and kidney qi deficiency group were compared with Yang deficiency water syndrome group,Differences were statistically significant(P<0.01,0.05).Comparison of phlegm-heat-deficiency syndrome group and lung-kidney-qi deficiency syndrome group,difference had no statistically meaning(P> 0.05).8.Three-type BNP comparison,Lung and kidney qi deficiency syndrome group,phlegm and heat syndrome group were compared with Yang deficiency type syndrome group,Differences were statistically meaning(P<0.01);Comparison of phlegm-heat-syndrome type syndrome group and lung-kidney-qi deficiency syndrome group,difference had no statistically meaning(P>0.05).9.In the phlegm-heat syndrome group,NEUT% had a positive correlation with ADPN,and there was statistical significance(P<0.01).There was no correlation between WBC and ADPN.There was no correlation between right ventricular end diastolic diameter,pulmonary artery pressure,BNP and AQP-5.10.In the lung and kidney qi deficiency syndrome group,There was no correlation between WBC and NEUT% and ADPN,There was no correlation between right ventricular end diastolic diameter,pulmonary artery pressure,BNP and AQP-5.11.In the Yang Xu water flood syndrome group,The WBC,NEUT % and ADPN no correlation.Right ventricular end diastole,pulmonary artery pressurewas a positive correlation with the AQP-5,have statistical meaning(P<0.01);The BNP have a positive correlation with the AQP-5,have statistical meaning(P < 0.05).Conclusion: 1.Lung distension phlegm heat yu lung syndrome and no correlation between serum ADPN in yu lung phlegm heat in the group with the increase of NEUT% ADPN is on the rise,ADPN may participate in the lung distension phlegm heat yu lung inflammation process.2.Lung distension Yang deficiency water pan card with no correlation between serum AQP-5,the Yang water pan in the group with the increase of PAP,BNP and RVEDd broadening,AQP-5 is on the rise,may participate in the AQP-5 lung expansion process of Yang deficiency water pan card fluid metabolism imbalance.