The Research On Rules Of Change From The Water Channel Of The Collecting Duct And The Interleukin-8 In Serum About Three Types Of Lung Distension

[Objective]: Follow the theory of traditional Chinese medicine and modern medicine theory perspective, with the AQP-2 and IL-8 as the main indexes, carry on clinical observation of Lung distension syndrome of water diffusion due to deficiency of yang,phlegm-heat obstructing lung syndrome,lung and kidney qi deficiency syndrome.Through the analysis and research of these three different types of lung distension on AQP-2 and IL-8 standard, to explore the correlation between three groups with AQP-2 and IL-8 standard.Then the inner conduct the thorough research to the pathogenesis of the syndrome from three types of Lung Distension to provide reference for clinical diagnosis and treatment.[Method]:Methods the investigation of clinical epidemiology was applied,using a randomized controlled design observation, according to the case selection criteria in30 cases of Lung distension syndrome of water diffusion due to deficiency of yang,27 cases of lung and kidney qi deficiency syndrome,47 cases of phlegm-heat obstructing lung syndrome,a total of 104 cases.According to the clinical manifestations,treated with Cardiac function,Pulmonary function evaluation,Cardiac ultrasound examination, Left ventricular ejection fraction, Pulmonary arterial pressure,Pulmonary function test:FVC/expected value,FEV1/expected value,FEV1/FVC.Using a double-antibody sandwich method to test AQP-2 and IL-8 standard. Observe three groups of clinical symptoms and signs of Lung distension as syndrome of water diffusion due to deficiency of yang, phlegm-heat obstructing lung syndrome,lung and kidney qi deficiency syndrome,and the changes of laboratory index. Evaluation theinfluence in lung distension such as AQP-2 and IL-8 and other laboratory indexes and symptoms.[Result]:(1)Compare the type:The order of IL-8 and AQP-2 between three groups is as follows:phlegm-heat obstructing lung syndrome group, lung and kidney qi deficiency syndrome group,syndrome of water diffusion due to deficiency of yang group,these results from patients all no statistical significance;(2)The relationship between the main symptom score and the level of AQP-2and IL-8: the change of the main symptom score of the patients was significantly positive correlated with the changes of serum AQP-2 and IL-8 levels, and it had a significant statistical significance;(3)The relationship between patient age, disease duration and AQP-2 and IL-8:AQP-2 level and age is positively correlated, IL-8 level and age were negatively correlated, but had no statistical significance; AQP-2 and IL-8 levels and the duration of illness was positively correlated, but there were no statistical significance;(4)AQP-2 and IL-8 were compared between patients with different levels of pulmonary function, and there was no significant between IL-8 and AQP-2 in patients with pulmonary function at all levels;( 5) AQP-2 and IL-8 were compared between patients at different levels of cardiac insufficiency, and there was no difference between IL-8 and AQP-2 in patients with heart function at all levels;(6)LVEF and PAP:EF of patients showed no differences, the difference was not statistically significant.There are positive correlation about EF to AQP-2 and IL-8,only the result from LVEF to IL-8 is significant.There is no significant about PAP come from kidney qi deficiency syndrome group to phlegm-heat obstructing lung syndrome group,the others are Significant statistical significance.There are positive correlation between PAP to AQP-2 and IL-8,all are significant;( 7) FVC/expected value FEV1/expected value and FEV1/FVC : There are negative correlation between FVC/expected value,FEV1/expected value,FEV1/FVC with AQP-2 and IL-8,these are significant except the result from FEV1/FVC and IL-8.[Conclusion]:In the serum of AQP-2 and IL-8 level directly affects the severity oflung expansion cards type in patients with primary disease;but not the syndrome types of the main basis for the identification of, also does not have a direct impact on cardiopulmonary function classification.The levels of IL-8 and AQP-2 in serum were predicted to FVC/expected value, LEVF and PAP of patients with lung expansion,and the decrease of FEV1/FVC and FEV1/FVC/expected value.The serum levels of AQP-2 increased with the increase of age and duration of the patients,and the degree of IL-8 in serum was attenuated.Along with the progress of the patients, the level of IL-8 and AQP-2 was same to change.In the end of the lung expansion,the syndrome types of heart failure and infection coexist.