Study On The Regularity Of Professor Meng Ru's Treatment Of Systemic Lupus Erythematosus Based On Data Analysis

Objective: Through the use of data analysis of the relevant methods,the state-level master of traditional Chinese medicine Professor Meng Ru as the treatment of systemic lupus erythematosus academic experience in the study,in order to explore its therapy with syndrome differentiation rule.Methods: Through the image acquisition and other methods to collect the supervisor to save Professor Meng Ru 1997-2000,2007-2010 diagnosis and treatment of SLE medical records.The data of medical records were standardized,standardized texts were obtained,and ACCESS was used to establish the database of the treatment of SLE cases by Professor meng.Excel 2013 Pivot Tables statistics of symptoms and signs,syndromes,syndromes and prescriptions of the frequency,using SQL Server 2012 MAddin data mining software and Using Apriori algorithm to analysis the roles for the treatment of systemic lupus erythematosus in Meng Ru Professor cases of main symptom,medicine and syndrome type-Symptom-drug-prescription.Setting the minimum support and confidence.At the same time,SPSS 21.0 and decision tree was used to analyze the main syndrome types and symptoms.And to sum up the regularity of Professor Meng Ru in the treatment of SLE.Result: 1.Frequency analysis results: The frequency of symptoms in the case data included in this subject is in the order of 10% and above:fatigue and lack of strength,nose and lips dry,red lips,insomnia,Lumbago,hot flashes,palpitations,joint pain,dry throat,facial erythema,hair loss,dizziness,thirst,dry and hard,skin erythema,upset,spiritlessness,pale red,limb soft,bitter taste,short yellow urine,eyelid edema,cough,dry lips;tongue with thin white fur,red tongue to see more,pulse fine pulse,slippery pulse.Syndrome differentiation of Qi and Yin deficiency,frequency 30.36%,followed by liver and kidney yin deficiency syndrome(26.39%),rheumatic fever arthralgia(10.91%),heat toxin syndrome(9.72%),twoof spleen and kidney deficiency syndrome(5.56%),the proportion is less.The disease in the syndrome of kidney(55.95%),liver(44.64%)as the main disease;disease of the syndrome of yin deficiency(86.11%),Qi deficiency(53.77%),wet(27.93%),heat(26.39%)for the common disease.In 260 cases,frequency analysis prescription 504 consultations,the use frequency of the top 15 are: erzhi pills,Shengmai Powder,Liuwei Dihuang pill,Zengye decoction;Suanzaoren Decoction,Zhibaidihuang pill,Xijiaodihuang decoction,Xiaochaihu Decoction,Dangguishaoyaosan,Huangqi Shengmai pills, Jiuwei Qianghuo Decoction,Juanbi decoction,Qinghao Biejia decoction and Qiju Dihuang pill,Pingweisan;The higher frequency of the top 40 drugs were used: liquorice,Poria cocos,radix rehmanniae,ophiopogon root,Cortex Moutan,yam,Alisma,dogwood,peony,Ligustrum,Eclipta alba,Rhizome of Chuanxiong,Schisandra chinensis,zhimu,angelica,bupleurum,banxia,white atractylodes rhizome,golden cypress,Radix Scrophulariae,the root of fangfeng,Scutellaria root,forsythia,raw oysters,semen coicis,Os Draconis,Su a ginseng,dried tangerine or orange peel,semen zizyphi spinosae,Zhishi,Rhizoma imperatae,large-leaved gentian,astragalus mongholicus,Sangjisheng,Chinese Atractylodes,Chinese bellflower,Artemisia annua,chrysanthemum,Radix Pseudostellariae,buffalo horn,is the main drug for treatment of SLE.Drugs to fill the virtual medicine,heat clearing drugs,and including blood circulation and blood stasis drugs,relieving exterior syndrome,diuretics for eliminating dampness and so on.2.The association rules and decision tree analysis results: the study of the main symptoms,traditional Chinese medicine and five kinds of common syndromes syndrome-symptom-drug-side association rules analysis,Analysis of Professor Meng Ru's treatment of SLE disease by symptoms Association rules,Close contact between the symptoms,Such as Lassitude and spiritlessness,weak limbs,palpitation,Hot flashes,tooth marks on the margins of the tongue,insomnia,thready pulse,white and thin coating of the tongue,hair loss close contact with symptoms;Upset and Irritable close connection;Throat-drying and bitter taste,red lip,thirsty,upset,facial redness,nasolabial fold close contact.From the analysis of drug association rules we know Professor Meng Ru treatment of SLE commonly used couplet medicines have rehmannia glutinosa-poria cocos,fructus corni-chinese yam,Ligustrum lucidum-eclipta and so on.Common drug combinations have “rehmannia glutinosa,fructus corni,chinese yam” “poria cocos,alisma orientale,paeonol” “su tiao shen,ophiopogon japonicas,the fruit of Chinese magnoliavine” “medicated leaven,hawthorn,semen Raphani” “peach seed,red flower,ligusticum wallichii,Chinese herbaceous peony,turmeric,astragalus membranaceus,angelica sinensis”and so on.From the drug dependence network can be summarized Professor Meng Ru's common prescription and core prescription for treating SLE.From syndrome type-Symptom-drug-prescription association rules analysis have known there are five common syndromes,Drug interactions and Common core prescriptions for each syndrome type.Decision tree analysis of syndrome type and symptom,Preliminary construction of Professor Meng treatment SLE liver and kidney yin deficiency syndrome,Syndrome differentiation of Qi and Yin deficiency,twoof spleen and kidney deficiency syndrome,rheumatic fever arthralgia,heat toxin syndrome diagnostic model of common syndromes.Conclusion: 1.Using the relevant data analysis method can extract the treatment rule of Professor Meng Ru in the treatment of SLE: such as the use of frequency analysis,we can induce high frequency symptoms,syndromes,prescriptions,and that supplementing qi and nourishing Yin,nourishing yin and clearing heat on treating systemic lupus erythematosus is the most common law relationship;Using association rule analysis can be drawn between compatibility rules the drug,symptoms and syndromes-disease-drug-side ";The use of decision trees can clearly reflect the relationship between symptoms and syndromes,so that the type of diagnosis of objective.Meanwhile further summarizes the academic experience of Professor Meng Ru in the treatment of SLE,like(1)Taking disease as the key link,Combination of disease and syndrome and treatment based on differentiation of symptoms and signs;(2)Focus on the whole,grasp the pathogenesis,detailed examination of the disease;(3)Good grasping the main symptoms,form and magnitude,the implementation of simple Yu Fan;(4)Keep the pathogenesis,use by the side,skilled in compatibility;(5)Good at drugs,seeking new synergies,efficiency attenuated.2.The use of modern data analysis method can analyze the clinical experience of the old Chinese medicine from many aspects and angles,so as to sum up the rule of syndrome differentiation and treatment,make the experience of the old Chinese medicine more intuitive,easy to understand and be able to get objective and practical conclusions.Clinical work has a guiding significance,and the old academic experience of traditional Chinese medicine research and traditional Chinese medicine development,innovation has important practical significance.