Study On The Distribution Of TCM Syndrome Factors And Medication Rules Of Systemic Lupus Erythematosus

Objective: This article collects,collates,and retrospectively analyzes the case data of patients with SLE(systemic lupus erythematosus)between January 2014 and December 2019 from Affiliated Hospital of Liaoning University of Traditional Chinese Medicine,in order toexplore the rule of Chinese medicine in treating SLE by data mining technology and literature research methods.Provide a reference for the diagnosis and treatment of SLE in Chinese medicine.Method:Formulate the inclusion and exclusion criteria,and establish a "SLE patient data database".Enter serial number,name,gender,age,admission time,symptoms,tongue,pulse,drugs and other information into Microsoft Excel 2016 one by one.Use IBM SPSS 22.0 software for frequency analysis,factor analysis and cluster analysis;use IBM SPSS Modeler 18.0 software for association rule analysis.Result:1.General condition: 258 cases of 149 patients were finally screened.There were 14 male patients(9.4%)and 135 female patients(90.6%).The male to female ratio was 1/ 10.64.Among the 149 SLE patients included in the statistics,the youngest was 15 years old and the oldest was 73 years old,with an average age of 46.14 ± 13.34 years.Among 149 SLE patients,the shortest course was 15 days,and the longest course was more than 40 years.2.Symptoms:A total of 82 symptoms occurred in all cases included in the statistics,with a total of 1892 occurrences,22 types of high-frequency symptoms,and a cumulative frequency of> 75%,which were: limbs pain,fatigue,insomnia,anorexia,thirst,chest tightness and shortness of breath,alopecia,facial erythema,swelling of the limbs,fever,cough,Raynaud's phenomenon,waist and knees tenderness,photosensitivity,edema,skin plaque,palpitations,dizziness,chills,cold limbs,diarrhea,uncomfortable urination,and oral ulcer.Factor analysis extracted high-frequency symptoms into 9 components.Cluster analysis clusters high-frequency symptoms into 9 categories.Symptom association rules: A total of 37 groups of association groups were obtained.Limbs pain and swelling were the mostobvious symptom combinations.3.Tongues and pulses: There are 13 types of tongues with a cumulative frequency of695 times.They are: pale tongue,red tongue,white tongue coating,thin tongue coating,dark tongue coating,less moss coating,yellow tongue coating,greasy tongue coating,bruised tongue,fat tongue,purple tongue,wet tongue coating,and tongue with tooth prints.There are 11 types of pulses,with a cumulative frequency of 411 times,which are: thin pulse,sunken pulse,wiry pulse,slippery pulse,rapid pulse,weak pulse,unsmooth pulse,tight pulse,soggy pulse,slow pulse,floating pulse.4.Drugs: 246 Chinese medicines were used in all cases included in the statistics,with a cumulative frequency of 3453.According to the overall frequency distribution of Chinese medicines,Chinese medicines with a frequency of more than 25 times were selected as high-frequency Chinese medicines,with a cumulative frequency of more than 60%,a total of 37 kinds,which were: Atractylodes macrocephala,Licorice,Astragalus membranaceus,Rehmannia glutinosa,Angelica,Coix seed,Poria,Chinese yam,Dogwood,root of herbaceous peony,Ophiopogon japonicus,Chuanxiong,root of herbaceous peony,Achyranthes bidentata,Scrophularia,Guizhi,Wolfberry,Moutan bark,Rhizoma anemarrhenae,Alisma,Rehmannia glutinosa,Oldenlandia diffusa,Salvia miltiorrhiza,Gypsum,Turtle shell,Bupleurum,Scutellaria baicalensis,Cortex phellodendri,Artemisia annua,Licorice,Honeysuckle,Cinnamon,Tangerine peel,Dangshen,Radix aconiti carmichaeli,Notopterygium,Dodder.Factor analysis extracts high-frequency Chinese medicine into 11 components.Cluster analysis clusters high-frequency Chinese medicine into 10 categories.Drugs association rules:A total of 32 association groups were obtained.Atractylodes macrocephala,Dogwood,Yam,and Astragalus membranaceus were the most obviously associated drug combinations.5.Syndrome Element:There are 10 types of pathogenic syndromes with a total frequency of 488 times.They are: Qi deficiency,Yin deficiency,Phlegm dampness,Blood deficiency,Fiery heat,Blood stasis,Yang deficiency,Cold,Wind,Qi stagnation.Among the 5 types of disease location syndromes,the cumulative frequency is 193.They are: kidney,spleen,liver,lung,and heart.The disease syndromes are mainly qideficiency,yin deficiency,phlegm dampness,blood deficiency,and fiery fever.The syndrome syndromes are mainly kidney,and the cumulative frequency is> 60%.A total of 32 related groups were obtained,with the most obvious combination of kidney and yang deficiency.6.Syndrome and drug: Atractylodes and Astragalus are more commonly used for Qi deficiency.For blood deficiency,Angelica,Atractylodes,Wolfberry,Scrophularia are mostly used.For yin deficiency,more Artemisia annua,Turtle shell,and,Rehmannia glutinosa were selected.Radix aconiti carmichaeli,Cinnamon,Astragalus and Atractylodes were selected for yang deficiency.Aiming at cold multi-purpose Notopterygium,Guizhi and Atractylodes.To cope with phlegm dampness,multi-purpose Coix seed,Cortex phellodendri,and Notopterygium are used.For pyrexia use of Gypsum,Rhizoma anemarrhenae,Cortex phellodendri and other drugs.For blood stasis,Chuanxiong,Achyranthes bidentata and Salvia miltiorrhiza are often used.The disease location element is the liver application of Artemisia annua,Turtle shell,Oldenlandia diffusa,Coix seed;the disease locatoin element are mainly applied in the spleen such as Dangshen,Alisma,Atractylodes and Poria;the pathological elements are mainly kidney apply Alisma,Yam,Radix aconiti carmichaeli and Turtle shell.Conclusions:1.The syndromes of SLE are mainly in the kidney,which are closely related to the spleen,liver,heart,and lungs.The disease syndromes are mainly deficiency syndromes,followed by solid syndromes.Deficiency disease syndromes are more common in qi deficiency,yin deficiency,and blood deficiency,and solid disease syndromes are mostly phlegm dampness and fiery fever.2.The disease location element are mainly kidney apply Alisma,Yam,Radix aconiti carmichaeli and Turtle shell.According to Qi deficiency,Atractylodes and Astragalus are used.For yin deficiency,more Artemisia annua,Turtle shell and Rehmannia glutinosa were selected.For blood deficiency,Angelica,Atractylodes,Wolfberry,Scrophularia are mostly used.To cope with phlegm dampness,multi-purpose Coixseed,Cortex phellodendri,and Notopterygium are used.For pyrexia use of Gypsum,Rhizoma anemarrhenae,Cortex phellodendri.