The Relationship Between Serum Alpha-fetoprotein Levels,Serum Carcinoembryonic Antigen Levels And Syndrome Of Phlegm Dampness In Patients With Nonalcoholic Fatty Liver Disease

Objective:The aim of the study was to determine the correlation between serum alpha-fetoprotein levels,serum carcinoembryonic antigen levels and syndrome of phlegm dampness in patients with nonalcoholic fatty liver disease.At the same time,to dicusse the relationship between serum alpha-fetoprotein levels,serum carcinoembryonic antigen levels and gender,age,BMI,sugar lipid metabolism index(FPG,QTC,TQ LDL-C,HDL-c,ALT,AST and GGT),blood pressure(SBP and DBP)and blood routine(RBC?WBC?LY?NEUT and MONO).This study can provide reference basis for the study of TCM syndrome in the treatment of nonalcoholic fatty liver disease.Methods:This study collected 721 cases of patients with physical examination,including 175 cases of patients with non alcoholic fatty liver,480 cases of normal persons.Non alcoholic fatty liver patients are divided into two groups,namely phlegm-dampness group(including 102 cases)and non-phlegm-dampness group(including 73 cases).The study also detected the serum AFP and CEA level of nonalcoholic fatty liver patients,At the same time recorded and analyzed patients serum AFP,CEA level and gender,age,BMI,blood pressure(SBP and DBP),sugar lipid metabolism index(FPG?TC?TG?LDL-C?HDL-C and ALT?AST?GGT)and blood routine(RBC?WBC?LY?NEUT?MONO).Results;1?The prevalence of NAFLD was 26.7%and increased significantly with age.The prevalence rate of male was higher than female(p<0.01),and there was a significant difference in different age groups(p<0.01).2.Compared with the normal group,the NAFLD group had high level of serum AFP and CEA level,the difference was statistically significant(p=0.010<0.05;p=0.002<0.01);At the same time,between the two groups,general index(gender,SBP,DBP,BMI),sugar lipid metabolism index(FPG?TC?TG?LDL-C?HDL-C and ALT?AST?GGT)and blood routine(RBC?WBC?LY?NEUT?MONO)all showed statistically significant difference(p<0.01).3.Spearman correlation analysis showed that AFP was correlated with BMI.TC.TG and GGT,while CEA was correlated with gender,age,SBP,FPG?WBC,NEUT and MONO.Stepwise regression analysis showed that in group of NAFLD patients,BMI has significant effects on serum AFP level(p<0.05);Gender,age,FPG have significant effects on serum CEA level(p<0.05).4.Compared with non-phlegm-dampness group,phlegm-dampness group had high level of serum AFP and CEA level,the difference was statistically significant(p=0.020<0.05;p=0.043<0.01).Phlegm-dampness group also had high level of SBP?BMI?TG?GGT?WBC?NEUT?MONO(p<0.05),suggest that hypertension,obesity,lipid accumulation,inflammation and other factors have important effects on the syndrome of phlegm dampness with NAFLD patients.Conclusions:1.Compared with the normal group,the NAFLD group had high level of serum AFP and CEA level,suggest that the determination of serum AFP,CEA,may be the new index of monitoring NAFLD progress and treatment.2.In NAFLD group,AFP was correlated with BMI?TC?TG and GGT and BMI was the independent factor of AFP,impy that AFP is closely related to liver lipid deposition,disorder of lipid metabolism,and insulin resistance and oxidative stress may be the key mechanism.While CEA was correlated with gender,age,SBP,FPS,WBC,NEUT and MONO,and gender,age,FPG was the independent factor of CEA,imply that CEA is closely related with age,blood glucose and inflammation.Insulin resistanceand inflammation may be the key mechanism.3.Compared with non-phlegm-dampness group,phlegm-dampness group had high level of serum AFP and CEA level,imply that AFP,CEA may be one of the pathological factors of phlegm dampness syndrome and can be used as objective indicators of phlegm dampness syndrome.4.Phlegm-dampness group also had high level of SBP?BMI?TG?GGT and WBC?NEUT?MONO,suggest that obesity,lipid metabolism,and inflammation are closely related with phlegm Phlegm dampness can be used as an important type of NAFLD,and is important to the prevention and treatment of TCM.