Analysis Of Sex Hormonein Levels Patients With Phlegm Dampness Type Polycystic Ovary Syndrome With Or Without Nonalcoholic Fatty Liver Disease

Objective:To compare the relationship between sex hormone levels in patients with phlegm-dampness PCOS and NAFLD and the difference of phlegm-dampness PCOS without NAFLD,to explore the main characteristics of sex hormone levels in patients with PCOS with/without NAFLD,and the relationship between wetted PCOS and NAFLD,To provide a basis for the prevention of long-term complications and clinical medication to improve the long-term quality of life of patients with PCOS.Methods:A total of 266 cases were collected from the clinical research and information integration system of gynecology clinic in the First Affiliated Hospital of Heilongjiang University Of Chinese Medicine in September 2015 to December 2016.All patients were diagnosed as PCOS phlegm dampness syndrome.All patients with phlegm-dampness PCOS were divided into two groups according to the diagnostic criteria of nonalcoholic fatty liver ultrasound,phlegm-dampness syndrome PCOS + NAFLD group 185 cases and simple phlegm-dampness syndrome PCOS group 81 cases.Clinical data including age,weight,waist and hip and other clinical indicators,hairy,acne,black echinoderms and other external signs and sex hormones 6,androgen 3,ALT,AST and other laboratory indicators.using SPSS 18.0 statistical software package for analysis,according to the results of the analysis to draw conclusions.Results:(1)There was no significant difference between the two groups in age,age at menarche(P>0.05).Phlegm-dampness syndrome PCOS with NAFLD group weight,BMI,WHR were higher than that of simple phlegm-dampness syndrome PCOS group,the difference was statistically significant(P<0.01),the two groups of BMI mean value was greater than 25KG/m2,WHR is greater than 0.8,belong to abdominal obesity.There was no statistically significant difference in the incidence of hirsutism,achenes and acne in patients with phlegm-dampness syndrome PCOS and NAFLD,but the incidence was higher(P>0.05).(2)T and AND levels in patients with phlegm-dampness syndrome PCOS and NAFLD group were higher than those of patients with simple phlegm-dampness syndrome PCOS,and the difference was statistically significant(P<0.01).At the SHBG level,the level of NAFLD in patients with simple phlegm-dampness syndrome PCOS was higher than that in patients with phlegm-dampness syndrome PCOS and the difference was statistically significant(P<0.01).There was no significant difference in LH,FSH,LH/FSH,P,PRL,E2,DHEAS between the two groups(P>0.05)(3)the ALT and AST levels of the patients with simple phlegm-dampness syndrome PCOS and phlegm-dampness syndrome PCOS with NAFLD group were different,the ALT and AST levels in phlegm-dampness syndrome PCOS with NAFLD group were higher(P<0.01).(4)the incidence of NAFLD in patients with phlegm-dampness syndrome PCOS correlated with BMI,WHR,AND,SHBG,and the BMI,WHR,AND are positively correlated,negatively correlated with SHBG,but showed a weak correlation.Conclusion:(1)Patients with phlegm-dampness syndrome PCOS with NAFLD have higher levels of androgen.(2)Patients with phlegm-dampness syndrome PCOS with NAFLD were more likely to have liver function change.(3)BMI,WHR,AND and SHBG are related to the occurrence of NAFLD in PCOS patients with phlegm dampness syndrome.