| Objective To analyze the clinical features and etiology of erythema nodosum, the objective of the thesis is to improve the therapy of erythema nodosumMethods Collected on January 1, 2005 to December 31, 2015, visits and ningxia medical university and department of rheumatology hospital dermatological department of the clinical data of 120 patients with nodular erythema, and their age, sex, course, clinical manifestation and laboratory examination indicators, using statistical methods to analysis and comparison, find rules of pathogenesis and characteristics.Using SPSS17.0 statistical software for statistical analysis of all indexes between count data by chi-square test, measurement data using analysis of variance, P < 0.05, with statistical significance.Result In 120 cases of EN, men have 22 cases patients, accounting for 18.33%;Women have 98 cases, accounting for 81.67%, the ratio 1:5.Onset age between 12 ~ 74 years old, the average age is 42.60± 13.76 years, average age of 42.61 ±13.77 years old male, female the average age of 42.14 ±13.68 years old. In patients with the highest incidence age 41 to 50 years old, the second is 31 ~ 40 years old, is 21 ~ 30 years old again. Highest incidence of male group is 31 ~ 40 years old, the second is 21 ~ 30 years and 41 to 50 years old. While women from high to low incidence group is 21 ~ 30, 11 ~ 20(11 ~ 15 years old have 3 people, 16 ~ 20, 14), 41 to 50 years.No statistical difference was found between men and women onset age. The average duration of 21.16 ±21.16 months, the shortest for 10 days, the longest as long as more than 20 years, including figures for march. In one of the men was 21.05 ± 46.88 months, a numerical value for march; Women was 21.91±47.67 months, the median values for march.10 days ~ 1 year, a total of 79 cases(65.83%), 1 ~ 5 years in 31 cases(25.83%), 5 ~ 10 years in 5 cases(4.17%), 10 to 20 years in 5 cases(4.17%)..Men's and women's course has no statistical significance. 120 EN patients all finshed the necessary checks from ningxia medical university general hospital, including routine blood, immunoglobulin Ig G, Ig A, Ig M, complement component C3, C4 and anti hemolytic streptococcus O(ASO), rheumatoid factor(RF), c-reactive protein(CRP) and antinuclear antibodies, and the degree of antinuclear antibodies, drops, and resistance to ENA antibody and erythrocyte sedimentation rate(ESR) examination. Laboratory tests have no obvious specificity. For further diagnosis, there are 31 biopsy results accord with tuberous erythema diagnosis.Conclusion 1. Erythema nodosum occurs in middle-aged women. The peaks is 41 to 50 years. The incidence ratio betweet men and women is 1:5. 2. The most common disease EN parts is double lower limbs pretibial area. The second was scattered limbs. 3. The diagnosis mainly depends on clinical manifestations and tissue pathology. 4. EN cause is multifarious, no specific laboratory examination indexes, for auxiliary reference only. 5. To clear EN the etiology of patients, improve the pathological biopsy and best tuberculosis related inspection, such as tuberculosis antibody, T- SPOT, looking for acid fast bacilli and related parts of the biopsy. |
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