| Objective: This research is one of the“twelfth five-year” national science and technology support research for new ways and new technology of safe contraception and the new sterilization technology. Our center is one center of many centers. Three different doses of mifepristone combined with misoprostol are used in women whose menstruation delay in 7 days for menstrual regulation and terminating pregnancy. The purpose is to compare the abortion rates of three different doses of mifepristone and misoprostol used in the terminating pregnancy and to observe the side effects of mifepristone and misoprostol and vaginal bleeding after medical abortion. Last, picking out the most suitable dose of mifepristone and misoprostol.Methods: The research object is 102 subjects who are voluntary to participate in the research and request to terminate pregnancy. The research subject come from the general hospital of Tianjin medical university and the people's hospital of Baodi on April 2013 to May 2015. They meet certain inclusion criteria and exclusion criteria and are divided into three groups. This study is a randomized double-blind comparative study. The subjects receive the Ru486 and PGE respectively according number( The previous research show that : Ru486 150 mg ? 100 mg ? 50 mg respectively combined with misoprostol 200 ug have a vevy low abortion rate,we had to terminate study, We restart this study after the adjustment of dosage of mifepristone and misoprostol). Method one: 100 mg Ru486,and then 600 ug PGE(36 to 48 hours later). Method two: 150 mg Ru486, and then 400 ug PGE(36 to 48 hours later). Method three: 200 mg Ru486, and then 200 ug PGE(36 to 48 hours later). According to the gynecological ultrasonic, vaginal bleeding situation, and urinary HCG outcome make a judgement of abortion outcome. The data were logged and analyzed with SPSS for Windows Version19.0. Single-factor analysis adopted descriptive method to calculate the rate. The qualitative data use chi square test and the quantitative data use single factor analysis of variance. Statistical significance was set at P<0.05,and the test level was a=0.05.Results: 1. The effect of abrotion and menstrual induction:The complete abortion rates of three methods are 90.9%, 90.6% and 90.3% respectively, and the incomplete abortion rates are 9.1%, 6.3%, 3.2% respectively. The outcomes do not have statistical significance. The percentage of gestational sac discharge of three methods are 48.5%?56.2%?64.5% respectively within 6 hours after taking PGE, and the outcomes do not have statistical significance. The average time of gestational sac discharge of three methods are 137.2min?212.6min?192.8min,method 1 is obviously shorter than the method 2 and method 3,the difference have statistical significance(P<0.05). 2.Side effect of RU486: The top three adverse reaction rates of Ru486 are nausea, abdominal pain, abdominal pendant. Nausea is the most common,the percentage of three methods are 42.2%?34.4%?38.7%,The incidence of the adverse effect of three doses Ru486 do not have statistical significance. 3.Side effect of PGE: The incidence of the top three side effects of PGE are 42.4%, 56.3% and 67.7% respectively. The top three adverse reactions of PGE are nausea, abdominal pain, abdominal pendant, the percentage of are 39.4%?34.4%?32.3%. The incidence of the adverse effect of three doses Ru486 do not have statistical significance. 4. Vaginal bleeding condition:The incidence of vaginal bleeding is 97.9%.Only 2.1% have no vaginal bleeding.The begin time of vaginal bleeding after Ru486 of three methods are 23.9 hours?21.8 hours?26.7 hours. The average time of duration vaginal bleeding are 8.7 day?9.8 day?9.8 day. The average time of duration vaginal bleeding do not have statistical significance.Conclution: 1.The three methods all have high complete abortion rates or low uncomplete abortion rates, and all of them are effective for women whose menstruation delay 7 days for terminating pregnancy. Because of all the research object are pregnant women, and no one non-pregnant women, so the effect of menstrual induction for non-pregnant women of low dose Ru486 or PGE still need a more study. 2. The rates of adverse reactions of RU486 and PGE are same in the three methods, and they are lower than the incidence of related reports.3. The vaginal bleeding time of three methods is same and shorter than the related reports. In conclusion, the three methods all can maintain a high abortion rates and lower adverse reaction rates, and can be applied in the women of menstruation delay 7 days, it is worthy for clinical application. |
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