Clinical Application Of Mifepristone Combined With Misoprostol In Painless Abortion During Pregnancy Of8-10Weeks

Objective:to study the clinical efficacy and safety by viewing women who are pregnant for8-10weeks and receive pretreatment using mifepristone and misoprostol before the painless abortion surgery.Methods:choosing pregnant women who are urged to give up pregnancy during8-10weeks in Tengzhou Workers’ Hospital from January2013to June2013. One hundred cases which meet inclusion and exclusion criteria, which are all booked operations and inhibited water and foods6-8hours before operations. Fifty pregnant women are randomly divided into two observation groups:on the basis of control group, taking mifepristone150mg at8p.m. before the operation; the second day at8a.m. performing the fentanyl propofol intravenous anesthesia under the painless induced abortion operation; half an hour sublingual misoprostol tablets containing400ug before operation. The control group:50cases directly using fentanyl combined propofolt to perform the painless induced abortion. Informed consent must be signed before surgery and anesthesia. Observe analgesic effect of the two groups, the degree of cervical dilation, drug dosage, operation time, intraoperative blood loss, postoperative bed time, and when the preoperative and postoperative uterine size, uterine contraction and intraoperative complication incidence (abortion synthesis reaction, leakage suck, suck palace is not complete, uterine cervical adhesion, etc.), the time of vaginal bleeding after operation, postoperative recovery time and menstruation, compares two groups of surgical efficacy, and safety.Results:the pain and cervical dilation of zero-level of observed group was significantly better than the control group.(1)anesthetic dosage:the observe group9.62±0.56ml, the control group13.08±1.03ml; Postoperative time from the bed:the observe group7.54± 0.67min,the control group12.32±1.39min, The difference was statistically significant, p<0.05;(2) the bleeding:the observed group16.59±4.38ml, the control group20.39±5.77ml; Operation time:the observe group3.42±0.26min, the control group4.38±0.43min, the difference was statistically significant, p<0.05;(3) the uterine cavity depth and preopera-tive and postoperative uterine contraction amplitude:the observe group4.38±0.43cm,8.37±1.38cm,1.86±0.31cmn the control group10.74±0.49cm,9.59±1.38cm,1.58±0.38cm, the difference was statistically significant,p<0.05;(4) there was statistical significance in the time of vaginal bleeding in both groups, p<0.05;(5) the observation group ofpatients with postoperative recovery time shorter than menstruation there was no statistically significant difference in the control group, p<0.05(6) the observation group and control group there was no statistically significant difference intraoperative complications compared, p>0.05.Conclusion:The8-10weeks painless abortion after mifepristone and misoprostol pretreatment, can achieve the result of the softening of cervical, thus effectively reduce the quantity of narcotic drugs, the bleeding and operation time. It can also improve uterine contraction, shorten the time of vaginal bleeding after operation and accelerate postoperative recovery time of menstruation. As a result, it can be used as the pretreatment before the8-10weeks painless abortion, so it is worth promoting.