| Objective:To investigate the effect of mifepristone and misoprostol in the treatment of8-12 weeks painless abortion patients in the operation and the safety of clinical treatment,to provide a safe and reliable basis for the 8-12 weeks of pregnancy to terminate pregnant patients to choose a more favorable abortion methods.Methods:114 cases of pregnant patients 8-12 weeks painless abortion in March 2015 ~June 2016 in our hospital for the study,all patients are in line with 8-12 weeks of pregnancy induced abortion-related standards,and both appointments surgery.All patients were randomly divided into group A and group B,57 patients in each group.Another patient admitted to our hospital 57 cases of medical abortion,as the group C.A group of patients using mifepristone and misoprostol in painless surgery on the basis of the following regimen: take mifepristone two days before operation,take50 mg in the morning,take 50 mg in the evening,take a total of 200 mg for two days.In the third embodiment painless abortion,and the implementation of misoprostol vaginally one hour before surgery.Group B patients following regimen: a simple implementation of painless surgery,the use of fentanyl propofol anesthesia.Group A and group B patients anesthesia(analgesia dose of narcotic drugs,the degree of cervical dilation),surgical conditions(operative time,blood loss,postoperative time away from the bed,changes in the uterine cavity,uterine contraction)observe and carry out comparative analysis and complication rate.Group A and group C analgesic effect,the degree ofcervical dilation and uterine contractions were compared.Group C with medication abortion,same given mifepristone and misoprostol,compared to group A and group C abdominal pain extent,the degree of cervical dilation,abortion effect and uterine contractions.Results:The pain condition of group A was better than group B and group C,there was significant difference(P <0.05)between them;A group of patients with cervical dilatation effective rate of 91.23%,cervical dilatation effective rate of group B75.44%,there was significant difference(P <0.05);the use of narcotic drugs and postoperative dose of group a patients from bed time were significantly better than group B(P <0.05);a group of patients the operative time and blood loss were significantly better than group B,the difference was statistically significant(P <0.05)between the two groups;after the implementation of painless surgery,there are significant differences in group a patients and surgical uterine cavity depth and better than group B,the difference was statistically significant between groups(P <0.05);the amplitude of uterine contraction in group A was significantly different from that in group B(P < 0.05);a group postoperative complication rate was 1.75%,group B postoperative complication rate was 5.26%,there is no statistical significance in the difference(P> 0.05);the vaginal bleeding in group A was significantly better than that in group B and C,and the difference between groups was satistically significant(P <0.05);the abortion effect in group A and group B was significantly better than that in group C,and there was significant difference between groups(P<0.05).A group of patients with postoperative recovery period were better than group B and group C(P <0.05).Conclusion:The implementation of painless surgery for 8-12 weeks pregnant before using mifepristone combined with misoprostol pretreatment,which could soften the cervix,shorten the time of operation and the time to leave the bed,reduce the amount of bleeding in the operation and the dosage of narcotic drugs,accelerate the uterinecontraction and reduce the bleeding of the vagina after the operation,and the menstrual tide is fast.Therefore,it can be used as a safe and effective pretreatment method in the clinical application of painless artificial abortion at 8-12 weeks of pregnancy. |
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