The Clinical Resesrch About Comound Mifepristone In Combination With Misoprostol For Terminating 8～12 Week's Gestation

Objective: To explore the clinical efficiency of compound mifepristone incombination with misoprostol for terminating 8-12 Weeks's gestation. To undertakethe differerntitation of symptoms and signs for classificatiom of syndrome for thoselong vaginal bleeding patients after dilation and curettage.Methods: A randomized comparative study in 105 pregnant women from theAffiliated Drum Tower Hospital of Nanjing University Medical School with normalor risked factors requesting medical abortion at 8～12 weeks's gestation.Women wererandomly divided into 2 groups.In group compound (n=53) women took compoundmifepristone one piece orally per 24h for 2 times (total dose: mifepristone 60rag andanordrin 10mg), and 48 hours later misoprostol 600μg orally.then, misoprostol givenvaginally every 4 hours, total dose of misoprostol were less than 1800μg perday.routine dilation and curettage were given after discharging embro and placenta, nomatter if they were completed;group unilateralism(n=52) women took mifepristonetwo pieces orally per 12h for 3 times (total dose: mifestone 150mg). same misoprostoland dilation and curettage as group compound.At the same time. we carry outdiffererntitation of symptoms and signs for classificatiom of syndrome.according tothe symptoms,vaginal bleeding,accompanied symptoms and signs.four physicalexaminations.There were QI-blood week type.stagnation of damp-heat type,stagnatedblood to hinder theuterus type and uncomsolidation of renal type.Results. The successful abortion rate from group compound to unilateralismwere 90.57％(48/53) and 86.54％(45/52) respectively;the complete abortion ratewere 81.13％(43/53) and 75％(39/52) respectively;the time of discharging embro andplacenta were 266.95±174.15 minutes and 253.7±148.70 minutes respectively. There were no significant differenecs (P＞0.05). After dilation and curettage,astheniasyndrome were 85％(17/20)和76％(19/25) respectively (P＞0.05),but the two setsinner were significant (P＜0.001); QI-blood week type were 64.15％(34/53) and57.70％(30/52) respectively. (P＞0.05);uncomsolidation of renal type were24.53％(13/53)and 15.38％(8/52)respectively(P＞0.05);stagnated blood to hinder theuterustype were 7.55％(4/53) and 19.23％(10/52) respectively (P＜0.05);stagnation ofdamp-heat type were 3.77％(2/53)和7.69％(4/52) respectively (P＜0.05)Conclution: Compound mifepristone in combination with misoprostol canterminate 8～12 Weeks's gesnation effectively. For those long vaginal bleedingpatients after dilation and curettage.the deficient syndrome was main., especiallyQI-blood week type.