Bushen Raw Bone Particles After Kidney Blood Type Postmenopausal Osteoporosis BMD, Serum E₂, BALP, N-MID

Objective: Observe kidney raw bone granules in the treatment of kidney and blood stasis type in postmenopausal osteoporosis clinical curative effect and advantage, provide more for clinical treatment of postmenopausal osteoporosis.Methods: Choose Chinese medicine hospital of city of Rizhao in August 2012 to December 2012, included in the standard of outpatient or hospitalization for complete follow-up data of kidney and blood stasis type of 120 patients with postmenopausal osteoporosis, randomized controlled method is adopted, the points in the treatment group(56 cases of oral kidney bone particles) and control group(56 cases of oral Gail, D). Observed two groups of patients before and after the treatment of clinical symptoms and signs improved, and bone mineral density(BMD) in both groups before and after treatment, serum levels of estradiol(E2), bone alkaline phosphatase(BALP), n-terminal osteocalcin(N- MID) the change of the index, comparing the treatment group and control group after treatment improve the situation.Results: 1. The clinical curative effect: treatment group total effectiveness 67.86% compared with the control group total effective rate 50.0%, was statistically significant(P < 0.05), treatment group curative effect is better than the control group.2.Efficacy: syndromes was 2. 89.29% syndromes curative effect of treatment group compared with control group 28.57%, with significant difference(P < 0.05), curative effect is better than the control group.3. After treatment, there were no changes in the control group after treatment serum E2, elevated serum E2 treatment group(P < 0.05); BMD in the control group and treatment group after treatment compared with statistical difference(P < 0.05), treatment group after treatment bone density increased significantly; BALP lower after treatment group and control group, N- MID lower, but the treatment group reduced more obviously, the treatment group and control group after treatment compared statistically significant(P < 0.05), the treatment group is better than the control group.4. Safe drug use analysis: the treatment group oral kidney raw bone particles 6 months review blood routine, urine routine, liver and kidney function, and treatment is no abnormal change before, no bad reaction.Conclusion:1. This study shows that kidney raw bone particles of kidney and blood stasis type Postmenopausal Osteoporosis(Postmenopausal Osteoporosis, PMOP) to improve the clinical symptoms has good effect, and can increase BMD, hints kidney and activating blood, liver spleen, raw bones strong gluten is an effective method for treatment of PMOP.2. Oral kidney raw bone granules on the patient's level of sex hormones, neurotransmitters and the regulation of bone metabolism indexes have certain effect, can be adjusted by the hypothalamus- pituitary- ovarian axis function, increase ovarian hormones level, regulating neurotransmitter, reducing bone resorption, promote bone formation, improve bone metabolism.3. 6 months after kidney raw bone particles are safe index inspection found no obvious side effects, patients with Chinese medicine kidney raw bone particles, oral safe and reliable, and can be used clinical promotion.