| 1?Objectives: This study aims to assess the effectiveness of Xiao-Yao-Shen-Huan-San and Paroxetine treatment for Gan-Yu-Pi-Xu-type post stroke depression through the NIHSS, TCM Syndromesof Gan-Yu-Pi-Xu, HAMD, and evaluate Shu-Gan-Jie-Yu,Jian-Pi-An-Shen can play a inmportant role in the treatment on Post Stroke Depression.These would provide a reliable basis and treatment ideas for the clinical treatment of Post Stroke Depression.2?Methods: A total of 60 Post Stroke Depression cases were selected as research subjects(all were from inpatients and outpatients of neurology, the sixth people's hospital of Fu Yang City between January 2014 to August 2015). They were randomly divided into two groups according to digital table method: Chinese medicine treatment group and control group with 30 cases respectively. Finally, 28 cases in treatment group and 28 cases in control group were included in our study afte remove shedding cases. On the basis of conventional treatment of stroke in two groups, treatment group was given Xiao-Yao-Shen-Huan-San(one dose daily; morning, noon, evening, three times a day) and Paroxetine(early 20mg), the control group was given oral Paroxetine treatment. After treatment for 2 weeks, 4 weeks and 8 weeks, NIHSS, TCM Syndromes of Gan-Yu-Pi-Xu,HAMD scores were used to evaluate the curative effect for two groups. The regular safety inspections during treatment were carried out for evaluation of Xiao-Yao-Shen-Huan-San treatment effectiveness.3?Results: After treatment for 2 weeks, 4 weeks and 8 weeks,, the within group comparisons of HAMD, NIHSS and TCM Syndrome Scale total scores were significantly lower than that before treatment(P<0.05); Comparisons between groups, three detection evaluation scores were decreased more than the control group with statistical significance(P<0.05). There were no differences in HAMD total scores between two groups after treatment for 2 weeks, 4 weeks, 8 weeks(P>0.05). However, the effective rate of Xiao-Yao-Shen-Huan-San plus Paroxetine was higher than the control grou.There were significant differences in TCM syndrome total scores for 2 weeks, 4 weeks,8 weeks(P<0.05). The total efficiency rates in TCM syndrome integral treatment group were 75%, 89.29% and 92.86% for treatment 2 weeks, 4 weeks and 8 weeks respectively.4?Conclusion: There was no significant difference in the in curative effect between Xiao-Yao-Shen-Huan-San puls Paroxetine and Paroxetine on Post Stroke Depression.But there are more efficient than Paroxetine alone. It was much better than Paroxetine alone in the improvement of TCM syndrome, depression, impaired function of the nervous system to restore, and in the treatment of Post Stroke Depression long-term effect, which also can reduce the adverse effects of Paroxetine. In summary,Xiao-Yao-Shen-Huan-San puls Paroxetine was worthy of recognition in the improvement of PSD close, long-term TCM syndrome, depressive symptoms,neurological function recovery and other aspects. The ideas in treatment for PSD patients with Shu-Gan-Jie-Yu and Jian-Pi-An-Shen is worth of spreading. |
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