Clinical Characteristics Of Patients With Peptic Ulcer Associated With Type 2 Diabetes Mellitus

Objective: Through compariting of peptic ulcer in patients with type 2 diabetes mellitus and simple peptic ulcer patients in ulcer occurrence location,size of ulcer,the number of ulcers,digestive tract symptoms,complications,the rate of Hp infection,Hp eradication and ulcer healing;compariting of the rate of Hp infection,the rate of Hp eradication and the rate of ulcer healing for groups of different duration of diabetes and groups of different Hb A1 c levels to explore the clinical characteristics of peptic ulcer associated with type 2 diabetes,and to provide guidance for further treatment.Methods: 106 patients with type 2 diabetes and peptic ulcer who came to our hospital form January-2013 to October-2015 were collected in an observation group,and 106 peptic ulcer patients without diabetes were collected in a control group.All took the fasting blood glucose assay and glucose tolerance test if necessary to except diabetes and impaired glucose tolerance.Gender,age and other general situation were compared for the two groups.The location of ulcer,maximum diameter,the number of ulcers,digestive tract symptoms,complications,the rate of Hp infection,the rate of Hp eradication and the rate of ulcer healing were compared for the two groups.The rate of Hp infection,Hp eradication and the rate of ulcer healing were compared for groups of different duration of diabetes and Hb A1 c levels.Results:1.The patients in the observation group were between the ages of 34-88 years,average age(63.77�11.13)years,the control group patients between the ages of 30-86 years,average age(63.57�10.18)years old.There was no difference between the two groups(P > 0.05).The observation group included 65 cases of male,41 cases of female;the control group included 74 cases of male,32 cases of female;there were no difference between the two groups(P>0.05).The duration of diabetes of the observation group was from1 months to 30 years,average(7.76 � 7.64)years.The patients with hypertension of observation group was 12 cases,patients with hypertension of control group was 8 cases,two groups had no significant difference between(P > 0.05).The patients with cholecystitis of observation group was 7 cases,and the patients with cholecystitis of control group was 4 cases,two groups had no significant difference between(P >0.05).The patients with hepatic adipose infiltration of observation group was 9 cases,The patients with hepatic adipose infiltration of control group was 5 cases,two groups had no significant difference between(P > 0.05).The patients with hepatitis B of the observation group was 2 cases.There was 1 case who associated with asthma in the observation group.There was 1 case who associated with lumbar disc herniation in the control group.2.The rate of gastric ulcer and compound ulcer for the observation group was significantly lower than that for the control group(P < 0.05).3.The rate of maximum ulcer diameter > 15 mm for the observation group was significantly higher than that for the control group(P < 0.05).The rate of ulcers with ulcer site>1 for the observation group was significantly higher than that for the control group(P < 0.05).4.The observation group patients who performanced for without digestive tract symptoms,bloating,early satiety were more than the control group(P<0.05),manifested as abdominal pain,acid reflux were less than that of the control group(P <0.05).There was no difference between the two groups in the number of patients with belching,nausea,diarrhea,constipation(P > 0.05).5.The rate of upper gastrointestinal hemorrhage for the observation group was significantly higher than that for the control group(P < 0.05).The rate of obstruction,perforation for two groups were no difference(P > 0.05).6.There was no difference in the rate of Hp infection between the two groups(P >0.05).The eradication rate of the observation group was lower than that of the control group(P < 0.05),and the rate of ulcer healing was lower than that of the control group(P < 0.05).7.The patients of the observation group were divided into three groups according to the duration of diabetes.The rate of Hp infection,Hp eradication,ulcer healing of three groups were analysed between every two groups.The outcomes were no differencese(P > 0.05).8.The observation group was divided into Hb A1 c ?7 group,and Hb A1 c < 7 group according to the levels of Hb A1 c.Hp infection rate between the two groups was no difference(P > 0.05);Hp eradication rate and ulcer healing rate of Hb A1 c ?7 group were lower than Hb A1 c < 7 group,the difference was statistically significant(P < 0.05).Conclusion:Peptic ulcer patients associated with Type 2 diabetes represented more gastric ulcers,multiple ulcers,more ulcers with maximum ulcer diameter>15mm,more ulcers with ulcer site >1,more ulcers combined with the upper gastrointestinal bleeding.Gastrointestinal symptoms were not typical,more patients represented abdominal distension,early satiety and no gastrointestinal symptoms.Less patients represented abdominal pain,acid reflux.Peptic ulcer patients associated with Type 2 diabetes had low Hp eradication rate,low ulcer healing rate.Hp infection rate,eradication and ulcer healing rate of different duration of diabetes groups were no difference.The rate of Hp eradication rate and ulcer healing rate of group Hb A1c?7 was lower.Peptic ulcer patients associated with Type 2 diabetes has its own characteristics,treatment needs to take into account these differences in order to develop more effective treatment options.