The Clinical Research In Treating Chronic Glomerulonephritis With The Type Of Spleen-Kidney Qi Deficiency By Yishenjianpitang

Objective:Through the research on the clinical effect of treating chronic glomerulonephritis by Yishenjianpitang and study on effect on patients’count of urine erythrocyte、24 hours urinary protein excretion、hemoglobin、plasna albumin, we try to explore the therapeutic mechanism from the western medicine view.Method:We devide the 60 chronic nephritis patients inclusion criteria packet randomly into treatment group (Yishenjianpitang group)and control group(Shenyanshupian group), and the two groups each contains 30 patients. Observe the change of symptoms、signs、clinical biochemical index before and after the treatment.Results:(1)Comparison between the two groups after treated 4 weeks and 8 weeks shows that the treatment group’s total efficacy is superior to the control group(P<0.05).(2)Total score comparison between the two groups after treated 4 weeks and 8 weeks suggest that TCM syndrome total score of the treatment group is better than the control group(P<0.05).(3)Both of the two groups can improve patients’syndrome integral and the treatment group is better than the control group(P<0.05),but the two groups after 8 weeks treatment and 4 weeks treatment don’t have significant differences (P>0.05).(4) The treatment group has significant effect in decreasing urine protein(P<0.01),but the control group hasn’t the effect(P>0.05).(5)The treatment group can decrease urine red blood cell count (P<0.01),but the control group hasn’t the effect (P>0.05).(6) The treatment group can increase plasma albumin(P<0.05),but the control group hasn’t the effect (P>0.05).(7) The treatment group has the effect of increasing the hemoglobin (P<0.05),but the control group hasn’t the effect(P>0.05).(8)The Yishenjianpitang has no significant toxic and side effects in the treating process, it is safe and reliable.Conclusion:From the results of the clinical observation,the Yishenjianpitang is superior than the Shenyanshupian generally. The treatment group is significantly better than the control group in improving symptom、decreasing urine red blood cells、decreasing urine erythrocyte of the 24 hours urinary protein excretion、elivating plasma albumin and hemoglobin (P<0.05 or P<0.01).