The Correlation Of MMP-9, ADMA And SCD40L And Ischemic Stroke, And Carotid Atherosclerotic Plaques

Objective:As the matrix metalloproteinases-9(MMP-9) and unsymmetrical dimethyl arginine(ADMA) and soluble CD40L(sCD40L) in-depth research, MMP- 9, ADMA and sCD40 L has an important role in the formation and stability in atherosclerotic plaque. Between MMP – 9 and ischemic stroke have some direct or indirect connection, and the same as ADMA and sCD40 L, but the connection is not very clear. This research mainly observed in the serum levels of MMP – 9、ADMA、sCD40L expression of ischemic cerebral apoplexy is different, the expression of carotid atherosclerotic plaques in whether has the difference, to screen effect of ischemic cerebral apoplexy and risk factors for carotid atherosclerotic plaques, providing for ischemic stroke and the prevention and treatment of atherosclerotic plaque with clinical data.Methods:Collecting in April 2015- November 2015 to neurology department and emergency department in chengde medical college affiliated hospital. Total of 198 cases of patients, including for 135 cases of ischemic stroke onset to hospital patients, as a group of stroke; Other causes without risk of ischemic stroke in the control group 63 cases as control group. Line neck artery color doppler ultrasound, on the basis of whether ischemic stroke is divided into stroke group and the control group, according to the results of color doppler ultrasound, divided into patches and plaques group, stable plaque group and divided into patches and unstable plaque group, on the basis of plaque number can be divided into single and multiple plaques group.Application of double antigen clip art(ELISA) detection in patients with serum of MMP- 9, ADMA and SCD40 L level, according to the comparison, different groups are parallel statistical analysis.Results:Stroke group compared with control group:, two groups of subjects of age, sex, there was no statistically significant difference(P > 0.05);Two groups of subjects of coronary heart disease, diabetes, smoking history, history of drinking, there was no statistically significant difference(P > 0.05);Two groups of subjects, serum TG, TCH, hdl-c leel of LDL- C contrast, there was no statistically significant difference(P > 0.05);The comparison of two groups of subjects hypertension, difference was statistically significant;Two groups of subjects of MMP- 9 contrast, there was no statistically significant difference(P = 0.067).Two groups of subjects serum sCD40 L, ADMA contrast, the difference was statistically significant(P < 0.05).Plaque group compared with no plaque group, two groups of subjects of age, sex, there was no statistically significant difference;Two groups of subjects of hypertension, coronary heart disease, diabetes, smoking history, history of drinking, there was no statistically significant difference(P > 0.05);Two groups of subjects of TG, HDL, LDL- C- C contrast, there was no statistically significant difference(P > 0.05);Two groups of subjects MMP- 9, ADMA contrast, there was no statistically significant difference(P > 0.05);Two groups of subjects sCD40 L, TCH comparison, the difference was statistically significant(P < 0.05).Plaque stability and unstable plaque group contrast, two groups of subjects of age, sex, there was no statistically significant difference(P > 0.05);Two groups of subjects of hypertension, coronary heart disease, diabetes, smoking history, history of drinking, there was no statistically significant difference(P > 0.05);Two groups of subjects, TG, TCH, hdl-c leel of LDL- C contrast, there was no statistically significant difference(P > 0.05);Two groups of subjects MMP- 9, sCD40 L contrast, there was no statistically significant difference(P > 0.05);Two groups of ADMA contrast experiment object, the difference was statistically significant(P < 0.05).Single plaques with multiple plaques group comparison: two groups of subjects of age, sex, there was no statistically significant difference(P > 0.05);Two groups of hypertension, coronary heart disease, diabetes, smoking history, history of drinking, there was no statistically significant difference(P > 0.05);Two groups of TG, LDL-C, TCH, hdl-c leel compared, there was no statistically significant difference(P > 0.05);Two groups of subjects MMP- 9, sCD40 L contrast, there was no statistically significant difference(P > 0.05);Two groups of ADMA contrast experiment object, the difference was statistically significant(P < 0.05).Conclusion:Serum sCD40 L, ADMA levels of stroke group was obviously higher than that of normal group, and the difference is statistically significant, prompt serum sCD40 L and ADMA levels associated with acute ischemic stroke events. Serum sCD40 L level of plaque group was obviously higher than that of no plaque group, and the difference is statistically significant, the stability of plaque group and unstable plaque group and single and multiple plaques group have no obvious difference in contrast, prompt serum sCD40 L level associated with the formation of plaques, is the risk factors of carotid atherosclerosis, predict the presence of atherosclerotic plaque. Serum ADMA level of unstable plaque group was obviously higher than that of stable plaque group, serum ADMA levels of multiple plaques group was obviously higher than that of single plaque group, and the difference is statistically significant, in plaque and plaque group have no obvious difference in contrast, prompt serum ADMA and the development of carotid atherosclerotic plaques and stability, and were not associated with the formation of carotid atherosclerotic plaques, predict the number of carotid atherosclerotic plaques and stability, and can be as predictors of instability carotid atherosclerotic plaques. We should further study of MMP- 9, sCD40 L and serum ADMA and ischemic cerebral apoplexy and the mechanism of carotid atherosclerotic plaques, for the prevention of ischemic cerebral apoplexy and treatment to provide new targets.