The Correlation Study Between Serum Endocan Level And The Formation And Stability Of Carotid Atherosclerotic Plaques And Ischemic Stroke

Objective: To explore the correlation between serum endocan(endothelial cell-specific molecule-1,ESM-1)level and the formation and stability of carotid plaques and large-artery atherosclerotic ischemic stroke.Measures:During October 2017 to October 2018,we consecutively collected 59 patients admitted to the neurology units of the Second Hospital of Hebei Medical University due to large-artery atherosclerotic ischemic stroke as infarction group.In the medical examination center,we constantly collected 80 subjects free of ischemic stroke whose carotid ultrasonography results demonstrated carotid plaques as plaque group and 40 subjects free of ischemic stroke whose carotid ultrasonography results demonstrated no plaque as plaque-free group.The serum endocan levels of the three groups are measured by ELISA(Enzyme-Linked Immunosorbent Assay).Compare the serum endocan levels between infarction group and plaque group,plaque group and plaque-free group.Evaluate the stability of carotid plaques of infarction group and plaque group by scores.The higher the scores,the more unstable the carotid plaques are.Make correlation analysis between serum endocan levels and carotid plaque scores of the two groups separately.Results:1.There is significant difference between serum endocan levels of infarction group and plaque group(37.18±7.97ng/mL vs 32.83±8.30ng/mL,P=0.002).2.Serum endocan level is positively correlated with carotid plaque scores in infarction group(r=0.490,P<0.001).3.No correlation is found between serum endocan levels and carotid plaque scores in plaque group(left: r=-0.034,P=0.762;right: r=0.041,P=0.719).4.No significant difference is found between serum endocan levels of plaque group and plaque-free group(32.83±8.30ng/mL vs 34.52±9.27ng/mL,P=0.318).Conclusions:1.Serum endocan levels in patients with large-artery atherosclerotic ischemic stroke are significantly higher than in people free of ischemic stroke.2.Serum endocan levels correlate negatively with the stability of carotid plaques in patients with large-artery atherosclerotic ischemic stroke.3.Serum endocan levels don’t correlate with the stability of carotid plaques in people free of ischemic stroke.4.The correlation between serum endocan levels and the formation of carotid plaques in people free of ischemic stroke is still unclear.