The Effect Of Periodontal Disease To Ischemic Stroke And Correlation Study Of Carotid Artry Atherosclerotic Plauqe

Objective:To investigate the effect of periodontal disease to ischemic stroke and explore on serum index, carotid artery atherosclerotic plaques with the degrees of periodontal disease and the influence of carotid artery atherosclerotic plaques on the people who had periodontal disease.Methods:According to the selected conditions,60 people with first-episode ischemic stroke in the acute phase of our hospital neurology department were admitted to the case group and 50 cases of control group. We investigated the general conditions of patients by using questionnaires and performed relevant tests for teeth respectively.To grade patients according to gingivitis index (GI), clinical attachment level(CAL) and teeth missing numbers and detect low density lipoprotein cholesterol (LDL-C),hyper-sensitivity C-reactive protein (hsCRP)and total plasma homocysteine(tHCY).To observe sclerosis of carotid intima-media thickness (CIMT) and plaques echo characteristics through the carotid color dopplar ultrasound examination. T-test was used to explore the gender differences in clinical variables of patients and use chi-square test to analyze the frequencies between groups. Logistic regression analysis was performed to identify all the clinical variables. The data were analyzed through the application of SPSS 17.0 software, and the difference was significant when p<0.05.Results:1. The teeth missing number, GI,CAL,LDL-C and tHCY represented significant differences between ischemic stroke group and control group (p<0.05). Those cases with more teeth missing, severe CAL, smoking, hypertension and high hsCRP accounted for a large proportion in ischemic stroke group represented statistical differences compared with control group(p<0.01).Thereinto, more teeth missing, severe CAL, smoking and hypertension were more significant (p<0.01).2. To mean ischemic stroke as dependent variables(ischemic stroke=l;no ischemic stroke=0).10 factors, such as gender, age, smoking, hypertension, education, hsCRP, tHCY, LDL, severe CAL and more teeth missing were independent variables. The influence of their risk factors can be seen in this order:hypertension(6.337)> severe CAL (5.840)> smoking(4.968) by odds ratio(OR) value from logistic regression analysis.3. Different degrees of periodontosis can make different influence on the formation of carotid artery atherosclerotic plaques, education age, hsCRP and tHCY, which represented significant statistical differences (p<0.05).4. To see periodontal disease patients as the research object and the formation of carotid artery atherosclerotic plaques as dependent variable(1=carotid plaques;0= no carotid plaques). 8 factors,such as gender, age, smoking, hypertension, education age, hsCRP, tHCY and LDL were independent variables. The factors that influenced the form of the carotid artery atherosclerotic plaques were choosed:high levels of hsCRP and tHCY,and the influence of their risk factors can be seen in this order:hsCRP (5.657)>tHCY (4.570) by OR value from logistic regression analysis.Conclusions:1. Average teeth missing,GI and CAL may have some relationship to ischemic stroke, especially those with server periodontal disease, which may play a premium on ischemic stroke.2. Severe periodontal disease may be one of the independent risk factors of ischemic stroke.3. Different degrees of periodontal disease made different influence on the formation of carotid artery atherosclerotic plaques, education age, hsCRP and tHCY.4. HsCRP and tHCY may be independent risk factors of the formation of carotid atherosclerotic plaques in the cases of periodontal disease.