Relation Between GXCL4、CXCL12 And Stable Carotid Atherosclerotic Plaques In Serum Of Patients With Acute Ischemic Cerebral Stroke

Objective:To investigate the relationship between serum platelet-derived chemokine CXCL4 and CXCL12 levels and stability of carotid atherosclerotic plaque in patients with acute cerebral infarction Methods:70 patients with ischemic cerebrovascular disease were selected as the research group who had been hospitalized in neurology department in our hospital from February2017 to November 2017,of which 47 cases of male,23 cases of female,its age range was from 25 to 75,the average age was 58.90±13.54.According to the application of color Doppler ultrasound,all subjects were divided into non plaque group,stable plaque group and unstable plaque group.At the same time,65 physical examination patients were collected whose indicators such as age,gender are comparable with the research groups as the control group who were diagnosised no cerebral vascular disease,of which43 cases of males,17 cases of females,its age range was from 25 to 75,the average age was 57.45±13.84.Then the levels of CXCL12 in serum of patients in the two groups were detected by the ELISA method,and the results were compared and analyzed.Results:Compared with control group,plasma CXCL4 and CXCL12 levels of cerebralinfarction group were obviously higher,differences was statistically significant;there was significant difference in the research group for Patients with three different types of levels of plaque CXCL12 in serum;In cerebral infarction group,unstable plaque group have a significantly higher levels of plasma CXCL12 than no plaque group(p < 0.05)and stable plaque(p < 0.05).There is a significant correlation between serum CXCL4,CXCL12 and the stability of carotid atherosclerotic plaque and differences was statistically significant(p<0.05).There is a significant correlation between CXCL4 and CXCL12 in the serum and differences was statistically significant(r=0.466,P<0.05).Conclusion:(1)Serum levels of CXCL4 and CXCL12 were significantly elevated in patients,suggesting that they may be involved in the occurrence of acute cerebral infarction.(2)The levels of serum CXCL4 and CXCL12 are closely related to the stability of atherosclerotic plaques suggesting that they may be involved in the occurrence of acute cerebral infarction.CXCL4 and CXCL12 may be the independent serological marker for predicting acute cerebral infarction and can be the important marker of external carotid artery plaque instability.(3)There is a significant correlation between serum CXCL4 and CXCL12 level,suggesting that the two have synergistic effect on the formation of carotid atherosclerotic instable plaque and cerebral infarction.