| Objectives To investigate the relationship between metabolic syndrome(MS) including its components and the Occurrence of endometrial cancer(EC).Methods A cohort of 19941 female workers according with Inclusion criteria was recruited in 2006~2007. Incidence of EC and other related outcome information were obtained by follow-up every two years and searching the related health condition databases every year and followed up for 6.99 years to examine the possible effect of MS on occurrence of EC. Multivariable Cox proportional-hazards regression model was used to calculate the RR(relative risk) and 95%CI(confidence interval) between the level of MS including its components at baseline interview and EC incidence adjusted for age group, body mass index(BMI),marital status(married and single), alcohol consumption(drinkers and non-drinkers) and tobacco smoking(smokers and non-smokers) when appropriate.Results By Dec 31, 2013, a total of 19941 females were enrolled in the cohort. There was 139290 person-year of follow-up with the mean follow-up period of 6.99±0.42 years. A total of 45 incident EC cases were collected. ①The proportion of the older women,BMI, waist circulation(WC), systolic blood pressure(SB P), diastolic blood pressure(DBP), fasting blood glucose(FBG), triglyceride(TG), marital status(single), and smoker were significantly higher while high density lipoprotein cholesterol(HDL-C),drinker were significantly lower in MS group than in n-MS group(all P<0.01).② The incidence rate of EC was 0.211% in MS group, while 0.169% in n-MS respectively(P<0.05).③ After adjustment for other traditional risk factors, the risk of EC in MS group was 1.96 fold(95%CI: 1.02~3.78)higher than in n-MS group. After adjustment for other traditional risk factors, the risk of EC in hyperglycemia( ≥5.6mmol/L)group was 3.18 fold(95%CI: 1.12~8.96)higher than in n-MS group.Conclusions 1 MS is an independent risk factor for EC. 2 Elevated levels of blood glucose at baseline interview might be associated with increased risk of EC. |
