| ObjectiveMetabolic syndrome(MS)is a concept for aggregationing metabolic components disorders,which include central obesity,dyslipidemia,impaired glucose tolerance,hypertension and associated with numerous serious complications.It is an important risk factor for cardiovascular disease.The studies had shown that serum high sensitivity C-reactive protein(hs-CRP)and oxytocin(OXT)are closely related to MS and its components.However,there have been no reports on the value of combined serum hs-crp and OXT in evaluating MS.The aim of our research is to investigate the correlation between serum hs-CRP-to-OXT ratio and MS,and analyse whether hs-CRP-to-OXT ratio provided more valuable on the risk assessment of MS than each value alone.MethodsA total of 168 subjects were recruited in this study.According to the unify criteria of JIS in 2009,the subjects were divided into two groups,MS patients(n=87)and non-MS subjects(n=81).A standard questionnaire,anthropometric characteristics include body height,weight and blood pressure were conducted by trained study personnel.Oral glucose tolerance test(OGTT)and insulin releasing test were performed.Blood sample was collected in all of the participants to measure serum glucose and insulin.The HOMA-IR(homeostasis model of insulin resistance)and HOMA-β(homeostasis model of β-cell function)were calculated by the formula.Serum hs-CRP levels(chemiluminescence method)and OXT concentrations(enzyme-linkedimmunosorbent assay,ELISA)were measured.Results(1)Compared with non-MS group,waist circumference(WC),waist-to-hip ratio(WHR),body mass index(BMI),HbA1 c,fasting plasma glucose(FPG),2h post-OGTT glucose(2hPG),systolic blood pressure(SBP),diastolic blood pressure(DBP),serum fasting insulin(FIns),2h post-OGTT insulin(2hIns),triglyceride(TG),total cholesterol(TC),homeostasis model of insulin resistance(HOMA-IR)in MS group were significantly increased(P<0.05 or<0.01),while homeostasis model of β-cell function(HOMA-β)and high density lipoprotein cholesterol(HDL-C)were significantly decreased(P<0.01).(2)Compared with non-MS group,the serum hs-CRP level of MS patients was significantly increased and the OXT level was significantly decreased(P<0.001),and the hs-CRP /OXT ratio was significantly increased in MS subjects(P<0.001).(3)Sectionalizing by the median of serum hs-CRP and OXT.Compared with the low hs-CRP-high OXT group,the number of MS components and detection rate of MS were higher in the high hs-CRP-low OXT group(P<0.001).(4)Serum hs-CRP-to-OXT ratio positively correlated with weight,WC,BMI,HbA1 c,FPG,2hPG,SBP,FIns,2hIns,TG,TC,hs-CRP and HOMA-IR(P<0.05),but negatively with HOMA-β,HDL-C and OXT(P<0.05).(5)According to the serum hs-CRP-to-OXT ratio levels,subjects were divided into tertiles,which include low concentration(T1 group),medium concentration(T2 group),high concentration(T3 group).The prevalence of MS was 21.4%,60.7% and 73.2% in the T1,T2 and T3 group,respectively.Those showed a significant rising trend(P<0.01).(6)In a logistic regression,The ORs of prevalence of MS in T2 and T3 group were 3.59(1.05,12.30),5.39(1.52,19.12)respectively,compared with T1 group after adjustment for sex,age,lipidprofile,BMI and HOMA-IR.(7)The area under receiver operator characteristic(ROC)curve of hs-CRP-to-OXT ratio [0.768(0.697,0.830)] to evaluate MS was significantly greater than that of hs-CRP [0.744(0.671,0.808)] or OXT [0.670(0.593,0.740)] alone.Conclusions(1)This study demonstrated that serum hs-CRP-to-OXT ratio in MS group was significantly increased compared with non-MS group.(2)With increasing level of the hs-CRP-to-OXT ratio,the morbidity of MS and the number of MS components were rising.(3)The serum hs-CRP-to-OXT ratio might more advantageous in evaluating MS than that of hs-CRP or OXT alone. |
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