| ObjectiveMetabolic syndrome(MS) is a concept for clustering metabolic disorders and is one of the most important modifiable targets for the prevention of cardiovascular diseases. Serum high sensitivity C-reactive protein(hs-CRP) and high-molecularweight adiponectin(HMW-APN) play important roles in linking MS. However, the relationships between serum hs-CRP and HMW-APN remain to be investigated. This study explored the association of serum hs-CRP-to-HMW-APN ratio with characteristics of MS and evaluated whether hs-CRP-to-HMW-APN ratio provided incremental information to predict MS than each value alone. MethodsA total of 170 subjects were enrolled in this study. The participants were divided into newly diagnosed MS patients(n=94) and age- and sex-matched non-MS subjects(n=76). Anthropometric characteristics were measured. Oral glucose tolerance test(OGTT) and insulin releasing test were performed and glucose, glycosylated hemoglobin(Hb A1C), insulin and blood lipids were measured in all of the included participants. Fasting serum hs-CRP concentrations were measured by chemiluminescence method and HMW-APN levels were determined by enzymelinked immunosorbent assay(ELISA). Results(1) Compared with the non-MS group, body mass index(BMI), waist circumference(WC), waist-to-hip ratio(WHR), fasting plasma glucose(FPG), 2 h post-OGTT glucose(2h PG), serum fasting insulin(FIns), 2 h post-OGTT insulin(2h Ins), Hb A1 C, homeostasis model of insulin resistance(HOMA-IR), systolic blood pressure(SBP), diastolic blood pressure(DBP), triglyceride(TG) in MS group were significantly increased(P(27)0.01), while high density lipoprotein cholesterin(HDL-C) and homeostasis model of β-cell function(HOMA-b) were significantly decreased(P(27)0.01).(2) Serum hs-CRP and hs-CRP-to-HMW-APN ratio levels were significantly higher in MS patients than non-MS subjects, while serum HMW-APN levels were significantly lower in MS patients than non-MS subjects(P(27)0.01).(3) The detection rate of MS and number of MS components were higher in the high hs-CRP-low HMW-APN group than that in low hs-CRP-high HMW-APN group(P(27)0.01).(4) Serum hs-CRP-to-HMW-APN ratio positively correlated with BMI, WC, WHR, SBP, FPG, 2h PG, Hb A1 C, FIns, 2h Ins, HOMA-IR, TG, total cholesterol(TC), low-density lipoprotein cholesterol(LDL-C) and hs-CRP(P(27)0.05 or P(27)0.01), but negatively with HDL-C, HOMA-b and HMW-APN(all P(27)0.01).(5) Participants were divided into tertiles according to their serum hs-CRP-toHMW-APN ratio levels. The prevalence of MS was 25.0%, 57.9% and 82.5% in the low, medium, and high concentration group, respectively. Increasing levels of serum hs-CRP-to-HMW-APN ratio showed a significant rising trend and were independently associated with MS(c2 = 37.470, df = 1, P(27)0.01).(6) Participants who were in the high hs-CRP-to-HMW-APN ratio group showed the highest relative risk of Met S after adjustment for age, sex, BMI, lipid profile and HOMA-IR. The adjusted-odds ratio(95 % confidence interval) of the highest tertile group were 4.80(1.18-19.56)(P(27)0.05).(7) Area under the curve of hs-CRP-to-HMW-APN ratio in receiver operator characteristic(ROC) analysis for MS was significantly greater than that of hs-CRP or HMW-APN alone. Conclusions(1) Our results indicated that serum hs-CRP-to-HMW-APN ratios were significantly increased in patients with newly diagnosed MS.(2) The trend in the presence of MS was more apparent in highest serum hsCRP-to-HMW-APN ratio tertile group.(3) Serum hs-CRP and HMW-APN might reciprocally participate in the development of MS. Hs-CRP-to-HMW-APN ratio might be a superior marker for predicting MS compared to hs-CRP or HMW-APN alone. |
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