Analysis Of Risk Factors Of Intracranial Infection After The Neurosurgery Craniotomy

Objective:Intracranial infection is a common complication afrer craniotomy. The factors that lead to intracranial infection are numerous, and a lot of studies about the factors that lead to intracranial infection have completed. However, due to the diffent medical environment and research mothods, the conclusions are also diffent. This study is to investigate the risk factors related to the intracranial infection afrer craniotomy, by the statistical analysis of the craniotomy patients’data in our hospital from Mar.2012 to Feb.2013. And, provide a reference for clinical to reduce infection after craniotomy.Methods:Retrospectively analyize the 356 patients after craniotomy, accurately record the massage include gender, age, diabetes, emergency surgery, operative time, Infratentorial (posterior fossa) surgery, prophylactic use of antibiotics, use of artificial materials, postoperative drainage tube, intensive care unit, postoperative corticosteroids, postoperative cerebrospinal fluid leakage of all cases. Then use SPSS 18.0 univariate drainage analyze the pre-quantitative risk factors, and screened the factors related to intracranial infection which have a statistically significant difference (P<0.05). Import these factors of statistically different into two logistic regression equation to do multivariate analysis, determine independent risk factor related to the intracranial infection after craniotomy. We can estimate the relationship between the independent risk factors and intracranial infection according to the calculated values of Exp (B).Results:In the 356 Collected cases,26 cases are infection, the infection rate was 7.3%. Univariate analysis found:diabetes,emergency surgery, operation time, infratentorial(posterior fossa) surgery, postoperative drainage tube, postoperative corticosteroids, postoperative cerebrospinal fluid leakage and prophylactic use of antibiotics are factors significant difference (P<0.05). Import these factors of statistically different into two logistic regression equations for multivariate analysis, the results show:postoperative cerebrospinal fluid leakage [Exp (B)=6.492] is the highest risk factors of this example, emergency surgery [Exp (B)=5.637], postoperative drainage tube [Exp (B)=3.375], Infratentorial (posterior fossa) surgery [Exp (B)=2.139] and postoperative corticosteroids [Exp (B)=1.851] are slso the independent risk factors for intracranial infection. Prophylactic use of antibiotics [Exp (B)=0.657] is the protective factors that prevent intracranial infection after raniotomy.Conclusion:1. The risk factor leading to intracranial infection atter craniotomy can besingle, or multiple. In this study, postoperative cerebrospinal fluid leakage, emergency surgery, postoperative drainage tube, infratentorial, infratentorial(posterior fossa) surgery, and postoperative corticosteroids are the independent risk factors leading to craniotomy postoperative infection. Opreative time and diabetes increase the chance of intracranial infection after craniotomy by synergy. Prophylactic use of antibiotics is the protective factors that prevent intracranial infection after craniotomy. 2. In this study, postoperative cerebrospinal fluid leakage [Exp (B)=6.492] is the highest risk factors of this case. Other independent risk factors are Emergency surgery [Exp (B)=5.637], postoperative drainage tube [Exp (B)=3.375], Infratentorial (posterior fossa) surgery [Exp (B)=2.139] and postoperative corticosteroids [Exp (B) =1.851].