Analysis On Risk Factors Of Intracranial Infection After Neurosurgical Craniotomy

Objective:With the development of modern medical science, intracranial infection is gaining more and more attention from people. To patients, being infected means that their lives are threatened, and that their families have to pay large amount of medical expenses. Therefore, we should actively explore the risk factors associated with intracranial infection so as to find out the preventive measures.Methods:The clinical data of patients in neurosurgery of Hospital of changchun city who survive for more than one week with intracranial infection after craniotomy for the past four years are collected. The risk factors of intracranial infection are assessed through establishing a database using Excel, making variable assignment and statistical analysis using SAS.8.02. For Single-factor analysis,measurement data use mean±standard deviation ( x?±S), count data use X2 tests; for multi-factor analysis,non-conditional multi-factor Logistics regression is adopted,with P <0.05 making statistically significant difference.Results:According to the diagnostic criteria for intracranial infection,2163 cases are analyzed,with 92 cases falling under intracranial infection,the infection rate being 4.21%.The results of single factor analysis are as follows. The average age of patients of the intracranial infection group (47.73±12.63) is higher than the patients of non-intracranial infection group(42.75±13.59). The average hospitalization days of patients of the intracranial infection group(24.20±4.87) was significantly higher than those of the non-intracranial infection group (15.81±4.74). The longer the operation time,the higher the intracranial infection rate:when the operation time <2h,the intracranial infection rate is 2.11%; when the operation time is 2h ~ 4h,the intracranial infection rate is 3.31%; when the operation time is 4h~6h,the intracranial infection rate is 6.43%; when the operation time is > 6h, the intracranial infection rate is 28.57%. The intracranial infection rate of the patients with diabetes before the operation (9.30%) is higher than that of the patients without diabetes before the operation(3.06%). The intracranial infection rate of the patients with hypertension prevalence before the operation (6.86%) is higher than that of the patients without hypertension prevalence before the operation(2.55%). The intracranial infection rate of the patients with lung infection before the operation (16.02%) is higher than that of the patients without lung infection before the operation(3.13%). The intracranial infection rate of the patients with extracranial malignant tumors before the operation (17.65%) is higher than that of the patients without extracranial malignant tumors before the operation(4.10%). The intracranial infection rate of the patients with disturbance of consciousness before the operation (5.34%) is higher than that of the patients without disturbance of consciousness before the operation(3.21%). The intracranial infection rate of the patients with tracheotomy after the operation (9.25%) is significantly higher than that of the patients without tracheotomy after the operation(3.25%). The intracranial infection rate of the patients with cerebrospinal fluid leakage after the operation (13.68%) is significantly higher than that of the patients without cerebrospinal fluid leakage after the operation(3.06%). The intracranial infection rate of the patients with ventricular drainage after the operation (12.82%) is significantly higher than that of the patients without ventricular drainage after the operation(3.54%). Patients' gender, surgical reasons, and surgical sites,surgical approaches,whether they have vascular disease before surgery or not,whether they use antibiotics before the operation or not,etc. have no significantly statistical relation with intracranial infection rates. The multi-factor non-conditional logistic regression analysis shows that the duration of surgery,diabetes before the craniotomy,high blood pressure before the craniotomy pulmonary infection before the craniotomy,cerebrospinal fluid leakage are independent risk factors of intracranial infection,and that the relative degree of risk are 2.0390,2.2600,2.1270,2.9720,2.8380 respectively. Conclusions:Age,hospitalization days,diabetes before the operation,hypertension prevalence before the operation,lung infection before the operation,extracranial malignant tumors before the operation,disturbance of consciousness before the operation,tracheotomy after the operation,ventricular drainage after the operation are risk factors of intracranial infection,the duration of surgery,diabetes before the craniotomy,high blood pressure before the craniotomy pulmonary infection before the craniotomy,cerebrospinal fluid leakage are independent risk factors of intracranial infection。...