Risk Factors Related To Intracranial Infection After The Removal Of Intracranial Tumor

Objective To explore the risk factors related to the intracranial infection after the removal of intracranial tumor in order to provide the basis for its prevention and treatment.Methods Of 479 patients who underwent a removal of intracranial tumor from 2010 to 2012 in our department, 66 had intracranial infection and 413 not,with the intracranial infection rates is 13.78%. Patients with insufficient clinical datas as well as emergency surgery were not included.The possible risk factors related to the intracranial infection were analyzed by the single factor analysis. The significant risk factors shown by the single factor analysis were analyzed by multivariate logistic regression analysis.Results The single factor analysis showed that risk factors related to the intracranial infection after the removal of intracranial tumor included more than 3 hours operative duration,posterior cranial fossa operation, mastoid air cells or sinus opening,older than 45 years old. The intracranial infection of craniotomy lasted more than 3 hours(15.95%) is higher than that less than 3 hours(6.42%)(P<0.05).The intracranial infection of posterior cranial fossa operation(34.07%)is higher than that of the supratentorial(9.02%)(P < 0.05).The intracranial infection of craniotomy with mastoid air cells or sinus opening(22.61%)is higher than that of not opening(10.99%)(P<0.05).The intracranial infection of patients older than 45 years(20.37%) is higher than that of the younger(8.37%)(P<0.05).The multivariate logistic regression analysis showed that the independent risk factors related to the intracranial infection after the removal of intracranial tumor included posterior cranial fossa operation, older than 45 years old(P<0.05).Concluion Posterior cranial fossa operation and older than 45 years old are independent risk factors related to the intracranial infection after the removal of intracranial tumor.