The Clinical Efficacy Of Warming Moxibustion Treatment Of Knee Osteoarthritis Research And Related Cytokines

PurPose To observe the curative effect of warming moxibustion treatment of KOAcomparing before and after warming moxibustion treatment of KOA patients serum IL-17,IL-18, TGF-βand FGF-2, IGF-1levels of expression, warming moxibustion treatment ofKOA part mechanism are discussed.Methods According to randomized controlled clinical trial design, will be included inthe standard of80cases of KOA patients were randomly divided into warming moxibustiontreatment group and control group (diclofenac sodium zyban),40cases in each group. warming moxibustion group selection Dubi,Zusanli, Xuehai, Heding, all are on both sides, thecontrol group oral Futalin, two groups are treatment1times a day,10times for a course, atotal of2course of treatment, treatment interval of2days.With “The Western Ontario and McMaster Universities (WOMAC) Osteoarthritis Index’’ in assessing curative effect before andafter treatment;Collect2groups of patients before and after the treatment of peripheral bloodserum, with double antibody sandwich enzyme-linked immunosorbent method detection,detection of two groups before and after treatment in Patients with serum IL-17, IL-18, TGF-βand FGF‐2, IGF‐1changes.The results by SAS8.0statistical software analysis.Said groupsof data are used), the comparison between the two sample t test, group compared withpaired samples t test, P <0.05for the difference was statistically significant.Result1.Clinical efficacy comparison: After treatment, warming moxibustion group that were26 cases, effective in12cases, total effective rate was95.0%, significantly higher than the72.5%(P <0.05), there was significant;2. WOMAC total scores:①total scores before and after treatment: comparison with the previous warming moxibusti-on group after treatment, pain, stiffness, and difficulty of daily activities WOMAC totalscores were lower, the difference was statistically significant (P <0.01); compared with thecontrol group after treatment before treatment the difference was not statistically significant(P>0.05);②After treatment groups WOMAC total scores: After treatment, warming moxibustion gro-p total score of60.56±12.20, group total score of85.85±11.66, warming moxibustiongroup WOMAC total score was significantly lower than the control group, the total score, thedifference was statistically significance (P <0.05,);3. Before and after treatment IGF-1, TGF-β and FGF-2level comparison: two groups ofpatients before treatment serum IGF-1, TGF-β and FGF-2level comparison, the differencewas not statistically significant (P>0.05); in the control group, serum IGF-1, TGF-β andFGF-2levels higher than before treatment (P>0.05), the difference was not statisticallysignificant; warming moxibustion group after treatment IGF-1, TGF-β and FGF-2higherthan before treatment (P <0.05), and higher levels after treatment (P <0.05), with statisticalsignificance;4.Two IL-17levels before and after treatment: Compared IL-17serum levels of the twogroups before treatment, the difference was not statistically significant (P>0.05); comparisonof serum IL-17levels after treatment, warming moxibustion after IL-17treatment group waslower than before treatment (P <0.05), and lower than the control group after treatment levels(P <0.05), with statistical significance;5. Two IL-18levels before and after treatment: Compare pre-treatment serum levels of IL-18in both groups, the difference was not statistically significant (P>0.05); comparison of serum IL-18levels after treatment, warming moxibustion treatment group after IL-18levels lowerthan before treatment (P <0.05), and lower than the control group after treatment levels (P<0.05), with statistical significance.Conclusion1. warm moxibustion treatment KOA significant clinical effect, is a clinically safe andeffective, and reliable method of treatment;2.After warm moxibustion treatment KOA, serum IGF-1, TGF-β and FGF-2expressionlevels were significantly increased, warm moxibustion promotes the IGF-1, TGF-β and FGF2-expression in the serum of patients with KOA may be one of the mechanisms of therapeuticKOA;3After the warm moxibustion treatment KOA, serum inflammatory cytokines IL-17, IL-18expression levels were significantly decreased efficacy of moxibustione on KOA’s, may berelated to inhibition of IL-17, IL-18expression levels related;4. KOA better efficacy of warming moxibustion treatment, IGF-1, higher serum levels ofTGF-β and FGF-2expression, and IL-17, IL-18expression in the lower level.