Association Between HLA-DRB1Alleles Polymorphism And Hepatocellular Carcinoma: A Meta-analysis

Objective:To investigate the correlation between HLA-DRB1*7/12/15and hepatic carcinoma.Methods: Articles were identified by an electronicsearch on PubMed、EMBAS、Wan fang data base、Chinese nationalknowledge infrastructure. Case-control study trials focusing on thecorrelation of the risk of HLA-DRB1*7/12/15with hepatic carcinoma wereincluded. Effective data were extracted from the eligible studies. All themeta-analyses were performed by RevMan5.0software. ORs were used aseffect indicators. Results: HLA-DRB1*12/15increased hepaticcarcinoma’risk of the whole population (OR=1.56,95%CI:1.12-2.17, P=0.009/OR=1.35,95%CI:1.03-1.77, P=0.03），while HLA-DRB1*7didn’tcorrelatedwithhepatic carcinoma’riskofthewholepopulation（OR=0.99,95%CI:0.46-2.14, P=0.97）； Subgroup analyzes suggested that:HLA-DRB1*12/15increased hepatic carcinoma’risk of Asian populations（OR=1.65,95%CI:1.17-2.32, P=0.004/OR=1.55,95%CI:1.14-2.11, P=0.006）， while HLA-DRB1*7didn’t correlated with hepaticcarcinoma’risk of Asian populations significantly （OR=0.95,95%CI:0.26-3.50, P=0.94）.Conclusions: HLA-DRB1*12/15increasedhepatic carcinoma’risk，while HLA-DRB1*7didn’t correlated with hepaticcarcinoma’risk significantly.