A Systematic Review Of The Effect Of Percutaneous Ethanol Injection Therapy On Small Hepatocellular Carcinoma

Objective To assess the effect,safety,and economics of percutaneous ethanol injectiontherapy on small hepatocellular carcinoma.Methods Computerized retrieve following electronic database:Chinese Bio-Medicine database,Cochrane library,MEDLINE,EMBASE .Appraised randomized control trials and non randomized control trials,abstracted data and synthesized with RevMan 4.2 for Meta-analysis.Results Seven hundred and eighty five titles were found,six study were included.We aggregate the data about survival of PEI and HR which was associated with a risk ratio. The RR of 1-year survival was 1.03, 95%C1 [0.97, 1.09] (p=0.39). The RR of 3-year survival was 0.97, 95%C1 [0.87, 1.09] (p=0.61).The RR of 5-year survival was 0.92, 95%C1 [0.61, 1.38] (p=0.67). The RR of 5-year recurrence was 1.24, 95%C1 [1.04, 1.48] (p=0.02).The averaged calculated cost per patient during follow-up was lower in the PEI group than in the HR group.The complications of two group patient was similar.