BackgroundBronchial asthma is a serious threat to human health of chronic diseases, it has no limitations of geographical and ethnic, and there was no obvious difference of age and gender. Every year the morbidity and mortality of increasing trend year by year, the world’s current asthma patients with an estimated300million, about250000people die each year from asthma, caused serious economic and social burden. At present cannot effect a radical cure of asthma, western medicine mainly to control inflammation target for clinical treatment. However, repeated use of western medicine for a long time tend to reduce asthma patient sensitivity to the drug, side effects such as drug dependence and failure. Treatment of asthma has a history of several thousand years of traditional Chinese medicine, in the long-term clinical practice, formed a relatively complete system of treatment, the years of clinical practice shows that traditional Chinese medicine treatment of asthma with high safety, reliable efficacy, side effects of small advantages, but always related to the clinical research of traditional Chinese medicine for asthma episodes or remission, lack of the whole process of the evaluation of curative effect observation.ObjectivesBy observing the patients ACT scores before and after the treatment, asthma symptoms score and lung function improvement, objective evaluation WenQing fill solid method, efficacy and safety of the treatment of bronchial asthma, in order to form a standardized, clinical operation, easy to promote combined bronchial asthma diagnosis and treatment plan;For further research and development of new drugs of Chinese medicine treating asthma research provide a new vision and perspective.MethodsObserved from June2012to July2013, guangdong hospital outpatient clear asthma type (TCM)"kechuanluo decoction" for patients129cases, were randomly divided into treatment group (WenQing fill solid method) of65cases and control group (ShuLi wad)64cases; Observation time for three months; Record the symptom scores of two groups of patients before and after the treatment, the ACT score, pulmonary function and the improvement of the quality of life score, etc. Records of two groups of patients before and after the treatment respectively ACT score, symptom scores, quality of life score and lung function improvement, etc.Results1. The asthma control test (ACT) score:ACT score after treatment in both groups all the time increased, the two groups in all the time, there was no statistically significant difference4weeks after treatment (P>0.05), and8weeks,12weeks after treatment differences statistically significant (P <0.05), the control group in8weeks after treatment of asthma control condition is better than that of the treatment group.2. The Asthma symptom score:Main symptom score after treatment in both groups all the time, the two groups in each time,1week,2weeks after treatment has no statistically significant difference (P>0.05), after treatment of4weeks,6weeks,8weeks,12weeks difference was statistically significant (P<0.05), suggesting the control group at4weeks after treatment control asthma condition is better than that of the treatment group.3. Asthma symptom scores at night:Symptom scores of two groups of patients with asthma day night each point all decreased after treatment, two groups in all the time,1week,2weeks,4weeks after treatment has no statistically significant difference (P>0.05),6weeks,8weeks,12weeks after treatment difference was statistically significant (P<0.05), six weeks after the control group in the treatment of asthma control condition is better than that of the treatment group.4. Adult asthma quality of life:Two groups of patients with adult asthma quality of life scores compared with before treatment increased;Comparing the two groups after treatment, there was no statistically significant difference (P>0.05).5. Lung function related indicators:To include complete cases pulmonary function index of110cases (treatment group of54cases, control group56cases) patients were analyzed. Both groups can improve the FEV1, FEV1/FVC, FEF25, FEF50, FEF75lung function index, such as lung function in the two groups after treatment, the indicators there was no statistically significant difference (P>0.05).6.The immune indexes:To include complete cases immune indexes of70patients (36cases treatment group and control group of34cases) were analyzed, and the CD4+/CD8+in the two groups after treatment, the difference was statistically significant (P<0.05), there was no statistically significant difference than index (P>0.05).7. Safety observation:In the process of treatment, there were7cases of adverse events. Among them2cases (treatment group and the control group (n=1), abnormal liver function in the process of treatment of traditional Chinese medicine group to stop taking Chinese traditional medicine and a half months later, self-medication with antibiotics (data) after1week to review the result of the blood, the western medicine group to stop sucking ShuLi lap3days after the results of blood; Control group1case appeared in the process of treatment of pulmonary infection,1case of headache after taking medicine, after symptomatic treatment, complete procedures; The treatment group1case in black also completed the study after taking the drug. After drug treatment group2cases of pharyngeal pain, abdominal distension and discomfort, asked to quit; More cases found no obvious abnormalities.ConclusionThis clinical research results show that the application of traditional Chinese medicine WenQing fill solid method treating bronchial asthma with1-3patients, it can improve asthma symptoms such as cough, asthma, chest tightness, reduce the number of asthma attacks, improve ACT score, improve the quality of survival in patients with asthma who, improve lung function. It may by regulating immune function such as CD4+, CD8+, lower serum EOS and other mechanisms to reduce airway inflammation and airway hyperresponsiveness, so as to achieve the purpose of the treatment of asthma. This study through WenQing complement fixation method of traditional Chinese medicine intervention for three months, long-term curative effect than the control group, treatment group can not be reached or not poor treatment between treatment group on conventional western medicine treatment, consideration is associated with less sample size and short course;In order to further in the future to carry out the relative large sample, prospective control study provides a new perspective and point of view. |