Literature Research On The Regularity Of Traditional Chinese Medicine In The Treatment Of Childhood Asthma

Purpose:Through sorting out the clinical treatment literature of asthma in children for nearly 30 years and the experience of famous old Chinese medicine,using the method of data mining,this paper finds out the combination and prescription of common drugs in the treatment of asthma in children,and provides a new clinical treatment idea.Material and methods:Search Wanfang database,Weipu database,Chinese journal full-text database,consult and screen the literature about pediatric asthma.The key words of the intervention were "traditional Chinese medicine" and "traditional Chinese medicine ",excluding " cough variant asthma "," application "," needle " and " acupoint ".The retrieval time was from January 1987 to December 2019.The retrieval expressions are as follows:TKA=(asthma OR TKATKA= asthma)AND(TKA= children OR TKATKA=children)(traditional Chinese medicine)NOT(TKA= variant asthma)(variant asthma)(application)(TKA= acupuncture OR TKATKA= point).Browse the retrieval results,after two screening,find out the documents that meet the requirements,use the Excel to sum up into a database,use Pivot Table function to analyze the frequency of related attributes,draw the conclusion of high-frequency traditional Chinese medicine,use IBM SPSS Statistics 22.0to cluster analysis,Use IBM SPSS Modeler 18.0 to analyze association rules and get corresponding results.Results:1.A total of 2857 related documents 1.retrieved,Read the title,The first screening meets the requirements of 551 articles,Read the full text,Finally,233 documents were obtained,A total of 292 prescriptions,Of 207 seizures,Mitigation period 85.Statistics and summary of asthma syndrome differentiation during the attack,In 90 cases,In 59 cases,Lung and kidney deficiency in 21 cases,13 cases of phlegm and blood stasis,Phlegm turbid 12 cases,Cold-wrapped heat asthma 12 cases;Syndrome differentiation,In 35 cases,Lung and kidney qi deficiency in 21 cases,Lung,spleen and kidney deficiency in 7 cases,Six cases of lung and kidney yin deficiency,Six cases of spleen and kidney yang deficiency,Qi deficiency,phlegm and blood stasis in 6 cases,Lung qi deficiency in 4 cases.2.There are 183 kinds of traditional Chinese medicine,The total frequency of using traditional Chinese medicine was 2423 times,There are 40 drugs more than 12 times,Of these,177 were ephedra,Bitter almonds 147 times.There are 19 types of drugs involved,The first five kinds of drugs are phlegm,cough,asthma,antipyretic,tonifying deficiency and calming the liver.Phlegm,cough,asthma,On behalf of Chinese medicine for bitter almond,perilla,Pinellia ternata;Of the antidote,Representative Chinese medicine for ephedra,Asarum,Guizhi.The four medicines are classified as warm,cold,flat,hot and cool,To warm,cold,flat.The order of five flavors is Xin,bitter,sweet,salty,sour,light,astringent,To Xin,bitter mainly.It is classified as lung meridian,spleen meridian,stomach meridian,heart meridian,liver meridian,bladder meridian,large intestine meridian,kidney meridian,gallbladder meridian,small intestine meridian,heart pericardium meridian,Jiao meridian,Among them,lung meridian is the most.A total of 146 kinds of traditional Chinese medicine were involved in 87 prescriptions in remission period,The total frequency of using traditional Chinese medicine was 1032 times,There are 43 drugs more than 8 times,Astragalus 60 times,The second was Atractylodes macrocephala 56 times,Licorice 55 times,Poria cocos 50 times,Chen Pei 41 times.There are 18 types of drugs involved,The first five kinds of drugs are tonifying deficiency medicine,eliminating phlegm,relieving cough and relieving asthma medicine,relieving surface medicine,astringent medicine and moisturizing medicine.On behalf of traditional Chinese medicine for astragalus,Atractylodes macrocephala,licorice;Resolving phlegm,relieving cough and relieving asthma represents traditional Chinese medicine for Pinellia ternata and Perilla.The four medicines are classified as warm,flat,cold,cool and hot,The main temperature.The order of five flavors is sweet,bitter,symplectic,sour,astringent,light,salty,To be willing.It is classified as spleen meridian,lung meridian,stomach meridian,kidney meridian,liver meridian,heart meridian,bladder meridian,large intestine meridian,gallbladder meridian,small intestine meridian,heart wrap meridian,three Jiao meridian,Among them,spleen meridian,lung meridian is the most.3.The results of cluster analysis were divided into 5 groups.C1: Ephedra,Asarum,Guizhi,Pinellia ternata,Chen Pei,Ginger.C2: Atractylodes macrocephala,Astragalus,Poria cocos,Glycyrrhiza uralensis,Schisandra chinensis.C3: peach kernel,salvia miltiorrhiza,rhubarb,Fructus Aurantii,Radix Paeoniae Alba,Dilong,Bombyx bassiana.C4 : Pinellia ternata,Qianhu,mulberry peel,perilla,Aster,mustard,bitter almond,winter flower,Platycodon grandiflorum,Fritillaria thunbergii,Fritillaria thunbergii,clam shell,Trichosanthes,Raphani seed,white fruit.C5: gypsum,honeysuckle,forsythia,shot dry,baicalin,houttuynia,cicada slough.The results of cluster analysis were divided into 7 groups.C1: jade bamboo,north ginseng,Ophiopogon japonicus,Fritillaria thunbergii C2: malt,chicken gold,Hawthorn,Raphani seed.C3 : Radix Pseudostellariae,Codonopsis,yam,licorice,Atractylodes macrocephala,White lentils,Astragalus,Poria cocos.C4 : oyster,keel,psoralen,dodder,cooked Rehmannia glutinosa,Ligustrum lucidum,Radix Paeoniae Alba,Cornus officinalis.C5: angelica sinensis,salvia miltiorrhiza,peach kernel.C6: Guizhi,Magnolia,Ephedra,Perilla,mustard,Aster,winter flowers,bitter almond,Platycodon grandiflorum,Pinellia ternata,Chen Pei,Fangfeng,Atractylodes.C7: dragon,silkworm,schisandra.4.Intermittent association rule analysis,With 125 results,Among them,Six rules of association,Three association rules,40,Four association rules 58,Five rules of association,All association rule elevations(gains)>1,Positive correlation.Summed up the following drugs,Ephedra-bitter almonds,Asarum-ginger-Schisandra,Ephedra ephedra-Perilla-bitter almond-licorice.Analysis of association rules during mitigation,With 152 results,Among them,Two rules of association,Three association rules 52,Four association rules 85,All association rule elevations(gains)>1,Positive correlation.The following drugs can be concluded: astragalus,Atractylodes macrocephala,Fangfeng,Pinellia ternata-Chen Pei-Fengfeng.Conclusion:1.according to the results of each analysis,we can know that the asthma drugs in the development period are composed of phlegm,cough,asthma,antiasthmatic,antipyretic,clearing heat and tonifying deficiency.The main drugs are ephedra,the most commonly used drugs are symplectic and bitter,the most commonly used drugs are warm drugs,and the most commonly used drugs are lung meridian,supplemented by spleen and stomach meridian.In the remission period,the main drugs are astragalus,Atractylodes macrocephala,Glycyrrhiza uralensis,the most commonly used medicine is Ganwei,the most commonly used medicine is warm medicine,the most commonly used medicine is spleen meridian,lung meridian,supplemented by stomach meridian,kidney meridian,liver meridian,heart meridian.2.Treatment of children asthma,attack should be mainly antiasthmatic and phlegm,heat,cold medicine,blood stasis medicine for each syndrome type,asthenia asthma should be taken into account,children often have more than the liver,so for some children,can be supplemented with anti-hepatic wind medicine treatment.In the remission period,the medicine is used to supplement the deficiency medicine and the phlegm medicine to treat its original,and the other kinds of drugs should be added according to the pathological factors of each syndrome type.3.According to the results of the analysis of the main composition of traditional Chinese medicine,are the main components of ancient classical prescriptions,the main representative prescriptions are Xiao Qinglong decoction,Ma Xing Shigan decoction,ginseng Schisandra decoction,Huagai San,Shenling Atractylodes Powder,Erchen decoction and other prescriptions.The common prescriptions in ancient times are closely related to clinical medication.In clinical diagnosis and treatment,they are closely related to the syndrome differentiation and classification of asthma in children,and provide a combination of ancient prescriptions and common drugs.