A Clinical Research Of Anzi Decoction Treating Threatened Abortion Induced By Luteal Phase Defect

Objective:Through clinical observing and monitoring serum sexhormones including estrogen(E2),progesterone(P),β-human chorionic gonadotropin(HCG),and B type ultrasonic,we explore the treating effect of AnZi decoction on early pregnant women diagnosed as threatened abortion induced by Luteal Phase Defect,who were deficiency of kidney and spleen (deficiency of Yang),or both while heat in blood and blood stasis (deficiency of Yin). To investigate its mechanism,clinical applications for the objective basis,and provide an safe and effective choice for patients of early threatened abortion.Method:120cases of clinical study were classified randomly into four groups after differentiation.The treatment group A were administered with AnZi I decoction,the treatment group B were administered with AnZi II decoction,while the controlled group A and B were intramuscularly injected with progesterone or(and) human chorionic gonadotropin for4weeks.The amelioration of clinical symptoms,serum E2、P、HCG,pelvic examination B-embryo development were determined before and after treatment among the four groups.Results:(1)Clinical effects:Treatment group A total effective rate was90%, total effective rate was86.7%in the control group A. Treatment group B the total effective rate was93.3%, total effective rate was83.3%in the control group B.Comparing the total effective rate of the treatment group and the control group, the difference was not statistically significant (P>0.05).(2)The efficacy of TCM syndromes:In improving Chinese medicine symptom,the total effective rate of treatment group A was93.3%, while the control group A was73.3%; the total efficiency of the treatment group B was90%,76.7%of the total efficiency of the control group B; Comparing treatment group and control group, the difference was statistically significant (P <0.05).(3) Tocolysis success rate:Tocolysis success rate of treatment group A was90%, control group A tocolysis success rate of86.7%, compared two groups, there was no statistically significant difference,(P>0.05).Treatment group B tocolysis success rate was93.3%, control group B tocolysis success rate was83.3%,compared two groups,there was no statistically significant difference,(P>0.05).(4) pregnancy hormones and gestational sac size:After treatment,the treatment group A/B and control group A/B have same efficacy in rising the level of serum E2, P,(3-HCG and promoting the growth of gestational sac size, the difference was not statistically significant between the treatment and control groups(P>0.05).Treatment group and control group serumE2, P,β-HCG levels were elevated after curing and compared with before treatment was statistically significant(P<0.05); but no statistical difference between the treatment group and the control group(P>0.05). B-monitoring in the treatment group and the control group after curing gestational sac size, shape, fetal heart beat, fetal forming the embryo development compared with that before treatment was statistically significant (P<0.05); but no statistical difference between the treatment group and the control group(P>0.05)(5) The security comparison:Treatment group and control group patients were no obvious abnormalities before and after treatment in blood, urine, stool routine tests and ECG,and did not appear obvious discomfortin the course of treatment.②Compared with before curing,the levels of serum ALT, AST, BUN and Cr levels of treatment group,the difference was not statistically significant (P>0.05),and so were the levels of serum BUN and SCR in control groups,but the difference of control group of serum ALT, AST levels was statistically significant (P<0.05); The comparison between the four groups after treatment:treatment groups and control groups, serum AST, ALT level comparison, the difference was statistically significant (P<0.05); serum BUN and Cr levels, the difference was not statistically significant (P>0.05).Conclusion:AN Zi I decoction, AN Zi Ⅱ decoction have significant clinical effect in treating threatened abortion caused by LPD that belong to spleen and kidney deficiency of Yin or Yang. AN Zi series of prescriptions can significantly improve clinical symptoms, significantly elevated serum estrogen (E2), progesterone (P), human chorionic gonadotropin (β-HCG) levels, and promote growth of the gestational sac, security is good, worthy of clinical.