Clinical Research About The Treatment On The Diabetic Nephropathy Of Detoxifying And Dia-Collaterals Baoshen Tang

AIM:To observe the curative effect of Detoxifying and dia-collaterals baoshen tang on the diabetic nephropathy and to study its mechanism.Methods:Patients with diabetic nephropathy who visited to Yanbian University Hospital and Changchun University of TCM from March,2008to March,2010, excepting patients who were complicated by double heart, renal inadequacy, myocardial infarction, nephrosis duty depletion, asthma, pulmonary infection, and advanced stage malignant tumor, were divided into Detoxifying and dia-collaterals baoshen tang treatment group (briefly called the treatment group)125cases and Benazepril treatment group (briefly called the contrast group)31cases. Two groups were not significantly different in gender, age, course of DM and the condition of patients (P>0.05). Detoxifying and dia-collaterals baoshen tang (is composed of medicines, that is, Milkvetch Root20g, Barbury wolfberry fruit20g, Coptis root5g, Weeping Forsythia Capsule15g, Glabrous Greenbrier Rhizoma30g, Honeysuckle flower20g, Common Anemarrhenae Rhizoma15g,Chinese wolfberry Root-barkl5g, Dan-Shen Root15g etc.) was infused by automatically boiling instrument. Benazepril was produced by Beijing Nuohua Pharmacy Company. The treatment course which is using basic treatment and Chinese、Western medicines unite treatment method, is one month, and all of the observation period is three month treatment course. The observation is whether the symptom improves or not before and after treatment,Fasting blood glucose(FBG), Glycosylated hemoglobin(HbAlc),Serum creatinine(Scr),Blood urea nitrogen(BUN),Serum cholesterol(CHO), Triglyceride(TG), High density lipoprotein cholesterol (HDL-C), Low density lipoprotein cholesterol(LDL-C), Blood rheology, Urine tests,24Hour urine protein quantitative changes, and Urinary albumin excretion rate(UAER) etc.Results:①Generally in efficiency the treatment group outperform the control group(P <0.05);②Detoxifying and dia-collaterals baoshen tang sigificantly improves clinical symptom of the patients with diabetic nephropathy (P<0.05);③Detoxifying and dia-collaterals baoshen tang has a good function to lower FBG And GHbA1(P<0.01);④Detoxifying and dia-collaterals baoshen tang significantly reduces24h Urine protein quantification. UAER of the patients with diabetic nephropathy (P<0.01);⑤In the treatment group, before and after treatment, BUN、Scr significantly dropped (P<0.01, P<0.05);⑤In the treatment group, serum CHO、TG significantly declined before treatment(P<0.05, P<0.01), but HDL-C elevated before treatment (P <0.01);⑦In the treatment group, the various indexes of blood rheoloy except the hematocrit improved in diverse degree as compared with before treated (P<0.05, P <0.01).Conclusion:Detoxifying and dia-collaterals baoshen tang in the treatment of diabetic nephropathy has satisfactory treatment effect.