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Study Of Clinical Observation And Evaluation On Quality Of Life On Treatment Of Yi Qi Runchang Method On Functional Constipation

Posted on:2013-01-28Degree:MasterType:Thesis
Country:ChinaCandidate:J S WangFull Text:PDF
GTID:2234330374491755Subject:Chinese medical science
Abstract/Summary:PDF Full Text Request
Functional Constipation(Functional Constipation,FC) is the intestinal dysfunction caused by constipation defecation, i.e. extended intervals of time; or not extended but difficult defecation, manifested as defecation frequency of less than3times a week, accompanied by poor bowel movement, extension of defecation time, less hard dung, or defecation incompletion feeling, and the various examinations revealed no organic disease. In recent years, as the change of dietary structure and social pressure and other factors, young and middle-aged people constipation incidence rates have increased year by year. Chronic constipation can lead to oral malodor, hemorrhoids, anal fissure, colon cancer and other complications, which seriously harm people’s physical and mental health. With the change of medical model from" bio-medical model" to " bio-psycho-social medical model ", psychological status and life quality of the patients with functional constipation gradually getting people’s attention. But at present, there has been no comprehensive evaluation of physical and mental health of the patients with functional constipation. During the treatment of functional constipation, defecate is paid more attention to. Stimulant laxative is usually used in Western Medicine, most of the patients in early stage may have varying degrees of ease, but the long-term use of stimulant laxative may result into drug resistance, some need to increase dosage, some totally lost effect, some of the patient may also produce drug dependence, with the appear namely"constipation without drug to treat" phenomenon. There are obvious advantages in the Chinese medicine treatment of functional constipation, it can play the overall regulatory role in the human body. But the excessive use of stimulant laxative can also result into drug resistance and intractable constipation. Therefore, the treatment of functional constipation can only stay in the simple purgative therapy, Yiqi Runchang method pay attention to the psychological status and living habits of functional constipation patients, achieving the purpose of complete cure constipation by giving comprehensive adjustment with drug treatment. Therefore, we treat intestinal dryness type functional constipation in Yiqi Runchang method and at the same time, make systematic evaluation of quality of life in patients with functional constipation, fully reflect the state of body and mind and prove the validity and superiority of Yiqi Runchang method in the treatment of this disease, in order to manifest the characteristics and advantages of the theory and clinical of traditional Chinese medicine in the treatment of functional constipation. 1.Clinical observation and evaluation of quality of life:Objective:To evaluate the clinical effect of the Yiqi Runchang method in the treatment of intestinal dryness type functional constipation and the quality of life of patients in order to prove the validity and superiority of Yiqi Runchang method in the treatment of intestinal dryness type functional constipationMethods:122cases of intestinal dryness type functional constipation were randomly divided into treatment group58cases and control group64cases, which were given Yiqi Runchang Decoction and Qirong Runchang oral liquid in the treatment. Course of treatment of4weeks., follow-up of4weeks, comparison of the two treatments of intestinal dryness type functional constipation by the observation of laxative effect, TCM syndrome integral, colonic transit test, safety.Result:The curative effect of clinical and TCM:treatment group clinical curative effective rate and cure rate (95%,56.67%) are higher than that of the control group (81.70%,16.67%), the difference is statistically significant (P=0.00). The treatment group TCM curative effective rate and cure rate (96.70%,51.67%) are higher than that of the control group (73.30%,26.67%), the difference is statistically significant (P.=0.009). Defecation quality:at the end of the treatment, the treatment group defecation quality level1subjects are more than those in the control group, the defecation quality level3subjects are lower than those in the control group, the two differences are statistically significant (P=0), manifesting Decoction of traditional Chinese Medicine in the improvement of defecation is superior to control drug group. The average onset time:treatment group25.65+14.98(hours), the control group35.95+24.37(hours), the differences of the onset time are statistically significant (P=0.015). Comparing to Qirong Runchang oral liquid, Traditional Chinese medicine decoction has the advantages of quick onset action, short onset time.The curative effect of individual symptom:In the4th week of course of treatment, Integral score of defecation interval extension, defecate and other symptoms in the treatment group is lower than the control group, and the difference is statistically significant (P<0.05); In the8th week of course of treatment, the score of defecation interval extension, defecate, stool and other symptoms in the treatment group is lower than the control group, the difference is statistically significant (P<0.05). The difference of Integral score of follow-up treatment group defecate symptoms In the8th week and4th week is statistically significant (P<0.05), the difference of the control group in defecation interval extension, defecate, stool integral In the8th week and4th week is statistically significant (P<0.05). The treatment group in improving defecation has the continued stability, controlled drug has the poor continued stability of improving the defecation interval extension, defecate, stool.The curative effect of Colonic transit test:The efficiency of colonic transit test in the treatment group is higher than that of the control group, the difference is statistically significant (P=0.002), Yiqi Runchang Decoction is better than Qirong Runchang oral liquid in improving colonic transit function. The cure rate of treatment group is higher than that in the control group, the difference is significant (P<0.05). Comparison between groups:the difference of markers remaining among24hours,48hours,72hours is not significant (P>0.05). Within group comparisons:treatment group:the difference of markers remaining before and after treatment among24hours,48hours,72hours is statistically significant (P<0.05),manifesting that the Traditional Chinese Medicine decoction can obviously improve the colonic transit function, control group:the difference of markers remaining before and after treatment among24hours,48hours,72hours is not statistically significant (P>0.05), manifesting that the Qirong Runchang oral liquid ia worse than Decoction of traditional Chinese medicine in improving the colonic transit function.The curative effect of continuous stability:At the end of the treatment, human subjects of defecation quality level1in the treatment group are more than those in the control group, human subjects of defecation quality level3in the treatment group are lower than those in the control group, the difference is statistically significant (P=0). In the4th week of course of treatment, Integral score of defecation interval extension, defecate and other symptoms in the treatment group is lower than the control group, and the difference is statistically significant (P<0.05); In the8th week of course of treatment, the score of defecation interval extension, defecate, stool and other symptoms in the treatment group is lower than the control group, the difference is statistically significant (P<0.05). The difference of Integral score of follow-up treatment group defecate symptoms In the8th week and4th week is statistically significant (P<0.05), the difference of the control group in defecation interval extension, defecate, stool integral In the8th week and4th week is statistically significant (P<0.05). The treatment group in improving defecation has the continued stability.Adverse reactions during treatment:1case of the research object from the control group exit the test for the intestinal obstruction;2cases of the research object from the treatment group showed a mild abdominal pain and diarrhea, with the symptoms disappearing after reducing medication2. Evaluation of the quality of life of patients with qixu intestinal dryness type functional constipation treated by Yiqi Runchang DecoctionObjective:evaluation of the quality of life of patients with functional constipation patients to reflect the level of quality of life.Method:evaluation of quality of life of observed object according to SF-36health survey scale in the week before and after treatment, the patients filled in the scale guided by the observerResults:the score of physical function, general health, vitality, vitality, role emotional and mental health were improved and statistically significant (P<0.05) after treatment.The score of role emotional in the control group was improved and statistically significant (P<0.05) after treatment,manifesting that Shirong Runchang oral liquid has less curative effect than Yiqi Runchang Decoction and certain limitations in the overall regulation of functional constipation patients.Comparison of the score of the treatment of life, treatment group, physical function, role physical, general health, vitality,role emotional, mental health in the two groups after treatment, the treatment group has higher scores than the control group, and lower score of bodily pain than the control group.The differences in the score of physical function and mental health were statistically significant, manifesting that the Yiqi Runchang Decoction can improve the patients’quality of life and especially physical function and mental health.Conclusion:Yiqi Runchang decoction has the validity and superiority in treating intestinal dryness type functional constipation and can improve the quality of life of patients with constipation to some extent.
Keywords/Search Tags:functional constipation, Yiqi Runchang decoction, clinicalobservation, evaluation of quality of life
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