The Association Between Blood Pressure Variability And Early Renal Injury In The Patients With Essential Hypertension

Objective To observe the association between blood pressure variability (BPV) andearly renal injury in the patients with essential hypertension.Methods A total of181patients with essential hypertension were enrolled in thisstudy. According to the urine album to creatinine ratio (UACR), all patients weredivided into two groups. The patients with UACR≤30mg/g were allocated intocontrol group (A group,120cases) and UACR>30mg/g into early renal injury group(B group,61cases).24h ambulatory blood pressure and the spot urineprotein-creatinine ratio were recorded.Results Mean SBP and DBP of24h, daytime, night-time were no statisticalsignificance between of the two groups (P>0.05). The parameter of BPV within thetwo groups all have a significant difference except for that of daytime’s BPV(P<0.05). Pearson correlation analysis showed that UACR was positive correlated tothe24hours systolic blood pressure variability,24hours diastolic blood pressurevariability, day diastolic blood pressure variability, nocturnal systolic blood pressurevariability, nocturnal diastolic blood pressure variability (r=0.274,0.319,0.232,0.395,0.342, P<0.01). Multiple linear regression analysis showed that UACR waspositive correlated to the nocturnal systolic blood pressure variability,24hoursdiastolic blood pressure variability, nocturnal diastolic blood pressure and triglyceride(P<0.05).Conclusion Nocturnal systolic blood pressure variability,24hours diastolic bloodpressure variability, nocturnal diastolic blood pressure and triglyceride have positivecorrelations with UACR and are related with early renal injury in the patients withessential hypertension.