The Relationship Between Short-term Blood Pressure Variability And Microalbuminuria In Patients With New Essential Hypertension

Objective to evaluate the relationship between blood pressure variability(BPVs)and microalbuminuria(MA)in newly diagnosed patients with essential hypertension,and to compare the average Real Variability mean Real Variability(BPV)and standard Deviation standard(BPV)in the evaluation of BPV.Methods 223 patients with primary hypertension were selected,including 105 males and 118 females,aged from 28 to 65 years,who were not treated with hypotensive intervention,including 105 males and 118 females.The average age was 50.9 ±12.1 years old.According to the MA results,the subjects were divided into MA positive group and MA negative group.All the patients were examined with blood and urine,including liver and kidney function,blood glucose,blood lipid,uric acid.Urine routine,routine,ask patients about smoking,drinking,measuring height,weight.24 mean systolic blood pressure(24h SBP)、24 mean diastolic blood pressure(24h DBP)was obtained by 24 hours ambulatory blood pressure,and further measured in sections.The blood pressure measured from 08: 00-18: 00 was daytime blood pressure,which was measured every 30 minutes.The daytime systolic(DSBP)and diastolic pressure(DDBP)was measured respectively,The blood pressure measured from 18: 00-08: 00 as nightly blood pressure.Measured every 1 hour,night systolic blood pressure(NSBP),night diastolic blood pressure(NDBP),and calculated SD and ARV at 24 hours and during the day and at night,respectively.the differences of ambulatory blood pressure between the two groups were compared,and multivariate analysis was carried out to understand the related risk factors of MA.Results 1.In the positive group,the systolic pressure of 24 hours was(137.4 ±12.06 vs 124.9 ±12.90,P < 0.01)the nocturnal systolic pressure was 134.9 ±11.97 vs 122.5 ±14.15(P < 0.01),and the daytime systolic pressure was 137.9 ±12.56 vs 1255 a.8 ±13.37(P < 0.01)highter than the MA negative group,with statistical significance(P < 0.05).2.In MA positive group,24 h systolic blood pressure SD(14.7 ±2.96 VS 12.5 ±2.6g,p<0.01)daytime systolic blood pressure SD(14.5 ±3.57 VS 11.9 ±2.84,p < 0.01),nocturnal systolic blood pressure SD(13.1 ±4.90 VS 11.1 ±4.28,P=0.04),24 h systolic blood pressure ARV(13.7 ±3.13 V S 11.3 ±3.30,P < 0.01),daytime systolic pressure ARV(12.3 ±3.13 vs 10.5 ±2.90,P < 0.01).All of them were higher than those of MA negative group(P < 0.05),but there was no significant difference in diastolic blood pressure DBP and nocturnal systolic blood pressure ARV between in the two groups(P > 0.05).3.By Logistic regression analysis,it was found that MA was independently correlated with 24 h mean systolic blood pressure,daytime mean systolic blood pressure,daytime mean systolic blood pressure SD1,and night systolic blood pressure SD1 24 h systolic blood pressure(ARV).Conclusion BPV is an independent risk factor for predicting renal dysfunction in early hypertensive patients.Both SDV and ARV can be used to evaluate BPVs.