Research On The Pattern Of Distribution Of TCM Syndrome Types Of Ulcerative Colitis

Object:To investigate the relationship between different TCM syndrome types of ulcerative colitis and clinical indexes such as age, disease course, stage, lesion range, clinical type, severity extent, endoscopic mucosa appearance and histological grade, to conclude the pattern of distribution of TCM syndrome types of this disease, to supply objective evidences to the TCM syndrome differentiation of UC and provide guidance for clinical diagnosis and treatment. Method:Summarize clinical and coloscopic data, merge the data, and conduct X2 test using the statistical software SPSS 19.0, analyzing the relationship between different TCM syndrome types of ulcerative colitis and clinical indexes such as age, disease course, stage, lesion range, clinical type, severity extent, endoscopic mucosa appearance and histological grade.Results:The frequencies of occurrences of different types of Ulcerative Colitis are:large intestine damp heat syndrome> spleen and stomach qi deficiency syndrome> spleen and kidney yang deficiency syndrome> intestinal blood stasis syndrome> liver depression and spleen deficiency syndrome> ying and blood deficiency syndrome.Young people mainly suffer from Large intestine damp heat syndrome and spleen and stomach qi deficiency syndrome, middle-aged people mainly suffer from spleen and stomach qi deficiency syndrome, and old people mainly suffer from spleen and kidney yang deficiency syndrome.Cases shorter than 5 years in disease course mainly express large intestine damp heat syndrome and spleen and stomach qi deficiency syndrome,5 to 10 years mainly express spleen and kidney yang deficiency syndrome and spleen and stomach qi deficiency syndrome, and longer than 10 years mainly express spleen and kidney yang deficiency syndrome.Cases in active stage mainly express large intestine damp heat syndrome and spleen and stomach qi deficiency syndrome, and in remission stage mainly express spleen and stomach qi deficiency syndrome and spleen and kidney yang deficiency syndrome.Cases involving with rectum and sigmoid colon mainly express large intestine damp heat syndrome and spleen and stomach qi deficiency syndrome, left part of colon mainly express large intestine damp heat syndrome, liver depression and spleen deficiency syndrome and spleen and stomach qi deficiency syndrome, regional colon mainly express intestinal blood stasis syndrome, and whole colon mainly express intestinal blood stasis syndrome and spleen and kidney yang deficiency syndrome.Initial onset mainly express large intestine damp heat syndrome, chronic recurrence mainly express spleen and stomach qi deficiency syndrome, large intestine damp heat syndrome and intestinal blood stasis syndrome, chronic continuous type mainly express spleen and kidney yang deficiency syndrome.Mild and medium cases mainly express large intestine damp heat syndrome, and severe one mainly express spleen and kidney yang deficiency syndrome, intestinal blood stasis syndrome and large intestine damp heat syndrome.Large intestine damp heat syndrome, spleen and stomach qi deficiency syndrome and spleen and kidney yang deficiency syndrome all manifest as hyperemia, edema and diffuse distribution on endoscopy appearance. The differences are:large intestine damp heat syndrome mainly manifests as erosion, ulcer and purulent secretion, spleen and stomach qi deficiency syndrome mainly manifests as spontaneous hemorrhage, spleen and kidney yang deficiency syndrome mainly manifests as rough, granular mucosa and spontaneous hemorrhage, and intestinal blood stasis syndrome mainly manifests as cavity stenosis and polyps.Histologically, cases in GradeⅠmainly expresses large intestine damp heat syndrome, GradeⅡmainly expresses large intestine damp heat syndrome and spleen and stomach qi deficiency syndrome, GradeⅢmainly expresses spleen and kidney yang deficiency syndrome and intestinal blood stasis syndrome.Conclusion:This study indicates there are significant correlations between different types of TCM syndromes of Ulcerative Colitis and age, disease course, stage, lesion range, clinical type, severity extent, endoscopic mucosa appearance and histological grade. Observation on indexes above and colposcopy could be clinically applied as extension of inspection, providing powerful objective indexes for TCM syndrome differentiation. This disease onsets and develops resulting from intrinsic deficiency and extrinsic virtuality acting on human body, and each of both act different parts in different stages of the disease. So in clinical treatment of UC, we should obey the principles that treat according to stage differentiation, combine systematic and local treatment, extrinsic and intrinsic treatment, and individualized treatment.