Type 2 Diabetes Yin Deficiency Clinical Phenotype And Serum No Correlation,

Diabetes is a clinical syndrome, mainly of glucose metabolic disorder. The number of China's rapid increase in diabetes has been in prevalence. It is estimated that China has 50 million diabetic patients, accounting for one in four of the total number of diabetic patients in the world, while each year the number increased to 1.2 million. Diabetes has become a new pandemic. Yin deficiency syndrome accounts for a large proportion of the nature of the diabetes. Yin deficiency plays a decisive role in its pathogenesis process, whose changes can be summarized as 'yin-hot-stasis', serving as pathological basis of vascular dysfunction. Nitric oxide (NO) is an endothelium-derived relaxing factor, which inhibits platelet aggregation, vascular smooth muscle cell proliferation and inhibition of leukocyte adhesion in the vessel wall to prevent vasospasm and thrombosis. In recent years many scholars have studied diabetic Yin deficienct syndrome in pathogenesis, differentiation, treatment, and experimental studies, in addition, successes have been there.This article is divided into two parts, the first part of the theoretical study, divided into two reviews. The first review-Progress of Chinese medical research on Yin deficient syndrome of type 2 diabetes-is including the pathological basis of diabetic Yin deficient syndrome, pathogenesis, differentiation, treatment, experimental study and so forth in the last ten years. The second review-Progress of modern medical research on NO abnormal metabolism in type 2 diabetes-is discussing various aspects including abnormal NO metabolism and the formation of islet cell dysfunction, diabetic vascular complication, diabetic neuropathy complication, diabetic nephropathy complication and so on.The other part is of clinical and experimental research, with the aim to explore the correlation between the two, clinical phenotypes of type 2 diabetic patients of Yin deficient syndrome and serum NO concentration, and the relationship of serum NO concentration and complications of type 2 diabetes, so as to see its possible mechanisms and to guide clinical treatment. This study collected 85 cases of type 2 diabetes, referring to the 'Chinese Medical Association Professional Committee of Diabetes in Chinese Tang Niaobing dialectical phases reference standards'developed in 1992 and 'Guidelines for clinical research of Chinese medicine and new drug' issued in 2002 by the State Drug Administration, dividing into four types of the deficient, and seven excessive types, analysing differences of the clinical phenotype of diabetic patients who agreed to be taken blood specimens for measuring NO concentration, a total of 24 cases. The research was between the two groups on differences of clinical phenotypes and serum NO concentration, correlation analysis of serum NO concentration and the clinical phenotypes of the two groups, that of serum NO concentration in diabetic patients and their Yin deficiency scores, and the differences of serum NO concentration in diabetic nephropathy, retinopathy, and peripheral neuropathy. Thus, it was possible to explore the mechanism of serum NO concentration in Yin deficient syndrome in type 2 diabetes.The results showed that there were linear relationship (P<0.05) among NO, N% Cr and BUN in diabetic patients, positively correlated, while there was no significant linear relationship among NO, WBC, L%, PLT, UA, and K+. The study also showed the result that linear relationship (P<0.05) among NO, N%, L% and Cr in Yin deficient patients with type 2 diabetes,, positively correlated, and the correlation coefficient r-of each index were over the correlation coefficient of each index of all diabetic patients, but no significant correlation among other clinical phenotypes. In the non-Yin deficient patients, NO was positively correlated with BUN and K+, but was not with other indexes. There was linear relationship (P<0.05) between NO concentration in serum and Yin scores of diabetic patients with negative correlation. It was significantly different of serum NO concentrations in diabetic complications (P< 0.05). There were no statistical differences in Chinese medical syndromes, in clinical phenotype of diabetic patients.Thus, the conclusion was as follows:serum NO was not only correlated with clinical phenotypes of diabetes, but also with that of Yin deficient syndrome and the deficient level, speculating that serum NO levels may serve as an indicator to judge the degree of diabetic deficiency. Moreover, serum NO was related with the occurrence and development of diabetic complications,Innovations:Through experimental determination of serum NO, correlation analysis was applied in the study of the relationship of clinical phenotype and Yin scores, speculating that serum NO levels may serve as an indicator to judge the degree of diabetic deficiency. There was no difference among the clinical phenotypes in diabetic patients.