The Soup Haoqin Mechanism Of Jaundice And The Principle Of Prescription Is Discussed

Objective:In this experiment,we use CCL4 to cause acute liver damage on mice, to simulate human body hepatocellular jaundice model.Then treated with HAOQINQINGDAN decoction low,mid, high dose therapy groups and Simeitai therapy groups,evaluating the level of ALT, AST, TB and DB in the serum. At the same time,make liver tissue pathology sections to know the function and mechanism of receding jaundice of HAOQINQINGDAN decoction,also for its organization principleMethod:Divide 60 mice into 6 groups at random,they are group A, B, C, D, E, F.A is normal group.ten mice are given.Then make the other 50 mice in building models all,after that still divide into Group B, C, D> E, F at random.Group B is pathological group , physiology brine is offered.C, D, E are given to 0.1625g/ml.0.325g/ml.0.65g/ml.density HAOQINQINGDAN decoction.F is Simeitai therapy group.We offer 6.5mg/ml density Simeitai intestine dissolvent tablet solution to this group.Begin to give medicine from the 17th day of building models.The gavage dose of each mouse is 30ml/kg one time a day,the total giving time is 10 days.Observe eating and moving states,as well as the colour changes of feces and urine of these animals.After evaluating the level of ALT, AST, TB, DB in the serum of the mice, handle them with statistics,make and observe Liver-tissue pathological sections.Result:1 symptom : :from the 10th day of building models.mice in the models groups began to have great difference from that in normal groups ?They move less,eat less.and the colour of their fur becomes dull.From the 12thday of building models.the urine colour of all mice in the building models groups becomes thick,to the 14th day,some of that even becomes asthick as strong tea.But normal group has no changes.While,from the 7th day of gavaging.mice in different dose of:HAOIQINGDAN decoction groups, their urineturns light , so is it with Simeitai therapy groups02 liver function changes of each group:The results of the experinent shows:Group C, D, E, F all can reduce enzyme and recede bulirubin.Compared with B, P<0.05.For C, D, E, F the four groups,the efficaly of reducing enzyme and reeding jaundice of Group D, E, F are superior to Group C.compared with C,P<0.05,among D, E, F.the level of ALT, AST, TB, DB of Group D, E are both lower than F. But compared with group F, the level of ALT, AST,P<0.05,the level of TB, DB, P>0.05.There is no difference between Group D and E.Conclusion:HAOQINQINGDAN decoction has the function of protecting liver and reducing enzyme and receding jaundice,Its mid and high dose groups are equal to Simeitai in receding jaundice,but superior to Simeitai in reducing enzyme.